日本分子生物学会

Click here for ConBio2017, the annual meeting in 2017 in Kobe
GTC cover art December 2017

December 2017
やけどに注意!完全手動PCR

You can perform polymerase chain reaction (PCR) without using a thermal cycler if you follow this drawing. Time management and temperature control are critically important for getting good yields of reaction products with high reproducibility and specificity. But, of course, safety first. Ouch! The smoke got in her eyes!
ポリメラーゼ連鎖反応(PCR)も、この画のようにすれば、サーマルサイクラーを使わなくとも実現可能である。再現性良く特異性の高い反応産物を高収量で得るには温度調節と時間管理が重要だが、もちろん安全を第一に。ああ煙が目にしみる!

GTC cover art November 2017

November 2017
GDF11の発現タイミングで決まる胴の長さ

The position of the hindlimb, or the length of the trunk, of tetrapods is highly diversified. Very recently, it was revealed that the timing of expression of Gdf11 gene in tetrapods' embryonic development plays an important role in determining the eventual position of the sacral vertebrae and the hindlimb beyond species. In some species that has a short trunk, such as frog, Gdf11 is expressed relatively earlier; in contrast, it is expressed much later in snakes' embryo. On the cover of this issue, we drew tetrapods with various lengths of the vertebrae, imitating Choju-jinbutsu-giga, one of Japan's national treasures, on a photograph of bamboos, which remind us of somites. For drawing this image, we referred to a website https://nagoyaumb5.wixsite.com/morphogenesis/takayuki-suzuki and a research paper by Matsubara et al. (2017) Nature Ecology and Evolution, vol. 1, pp.1392-1399, DOI: 10.1038/s41559-017-0247-y.
四肢動物の後肢の位置、すなわち胴の長さは多様性に富んでいる。ごく最近、四肢動物の胚発生におけるGdf11遺伝子の発現のタイミングが、種を超えて仙椎と後肢の位置の決定に重要な役割を果たしていることが明らかとなった。カエルのように胴の短い種ではGdf11が早いタイミングで発現するのに対し、ヘビの胚ではその発現のタイミングが非常に遅い。今号の表紙画では、体節を想起させる竹林の写真に、日本の国宝である鳥獣人物戯画に似せた筆致で様々な長さの脊椎を持つ四肢動物たちを描いた。作画にあたって以下のWebサイトと論文を参考にした。https://nagoyaumb5.wixsite.com/morphogenesis/takayuki-suzuki および Matsubara et al. (2017) Nature Ecology and Evolution, vol. 1, pp. 1392-1399, DOI: 10.1038/s41559-017-0247-y.