There is an exciting new opportunity at the University of Southern California for highly motivated postdoctoral candidate(s) committed to developing a successful career in chromatin biology or stem cell biology. Our lab has extensive expertise and excellent track record in studying epigenetic regulations of cell fate determination using embryonic stem cell, or cancer cell as the model. We employ multidisciplinary approaches to understand the functions of histone modifying enzymes in a variety of physiological and pathological processes.
Responsibilities include a) Developing novel approaches to characterize epigenomes in stem cells and cancer cells, b) Conducting cellular, molecular and in vivo experiments for hypothesis-driven research, and c) Preparing presentations and publishing scientific manuscripts under the direction of the Principal Investigator. Candidate will enjoy a highly collaborative environment in Dou lab as well as USC research community. It is essential that the applicant has excellent organizational and communication skills. The postdoctoral trainees will be encouraged to submit their own fellowship and grant applications during their periods of training.
Applicants should hold a PhD or be close to the completion of a PhD. Degree in Molecular and Cellular Biology, Genetics, Developmental Biology, or in a relevant field. Experience with standard molecular and cellular biology techniques and familiarity with genomic technologies are essential. Experience in performing epigenomic assays (CRISPR/Cas9, ChIP-, ATAC-, 4C-seq) will be a plus but not required. The ability to learn new techniques quickly and a strict attention to details of experimental protocols are required.
Interested candidates should send a CV to Dr. Dou (yalidou[at]usc.edu), Professor of Medicine and Co-leader of the Genomic and Epigenomic Regulation Program in the USC/Norris Comprehensive Cancer Center.
Representative publications (2018-2021):
Histone acetyltransferase MOF regulates quiescence in ground-state pluripotency through fatty acid oxidation. Cell Stem Cell, 27(3):441-458, 2020.
Cryo-EM structure of the human Mixed Lineage Leukemia-1 complex bound to the nucleosome. Nature Communication, 10(1):5540. doi: 10.1038/s41467-019-13550-2, 2019.
Facile target validation in an animal model using monobodies. Nature Chemical Biology, 14(9), 895-900, 2018.
HOXA9 reprograms the enhancer landscape during leukemic transformation. Cancer Cell, 34, 643-658, 2018.
Postdoctoral Fellow Position in Regenerative Biology
University of California San Francisco, San Francisco, USA
We are seeking highly motivated candidates with interests in regenerative biology to join Dr. Huang’s laboratory at UCSF (website: http://www.cvri.ucsf.edu/~huang/lab/Research.html). The laboratory uses the heart as a model system to investigate organ development, regeneration and repair in adult zebrafish, neonatal and adult mice, with an emphasis on the pathways that regulate resident stem cell activation and mature cell dedifferentiation/proliferation, and with innovative and integrated approaches in single cell analysis, advanced imaging microscopy and genome manipulation technology.
1. Developing novel intravital imaging in live animals and tissue clearing techniques for high-resolution visualization of cellular behavior, activity and interaction during heart development and regeneration.
2. Performing functional screens to induce adult mouse and human cardiomyocyte regeneration using both candidate gene and directed evolution approaches integrated with CRISPR/Cas9 genome manipulation technology.
3. Taking pharmacological and genetic approaches to uncover the unifying principle governing the decline of regenerative potentials in adult mammalian organs and appendages including the heart, digit/limb, skin, brain, and spinal cord.
4. Leveraging the power of phylogenetic screen to identify novel mammalian animal models with extraordinary tissue regenerative capacity.
5. Investigating human genetic mutations and underlying molecular mechanisms in rare heart diseases that may result in preservation of cardiac regenerative potential.
6. Exploring the molecular basis of extreme biology in invertebrate and vertebrate species including water bears, naked mole-rats and ground squirrels.
We invite candidates with a highly productive training record, strong research motivation, and extensive experience in any of but not limited to the following areas: (1) developmental and regenerative biology, (2) heart physiology and cardiomyocyte biology, (3) cell division, signaling, and bioinformatics data analysis. Successful candidate will work in a highly interdisciplinary research program that interfaces developmental and stem cell biology, regenerative medicine, and cardiovascular diseases.
1. Hirose, K., Payumo, A., et al. & Huang, G. N. (2019) Evidence for hormonal control of heart regenerative capacity during the acquisition of endothermy. Science 364(6426): 184-188.
2. Payumo, A. & Huang, G. N. (2020) Lamin B2, guardian of cardiomyocyte nuclear division. Dev Cell 53:5-6
3. Huang, G. N., et al. & Olson, E. N. (2012) C/EBP transcription factors mediate epicardial activation during heart development and injury. Science 338 (6114): 1599-1603.
4. Huang, G. N., et al. and Worley, P. F. (2008) NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Science. 319 (5862): 476-81.
Guo Huang, Ph.D.
A postdoctoral position is available
Thomas Jefferson University, Sidney Kimmel Medical College, Genome-Wide tRNA Epigenetic Biology
A postdoctoral position is available with Professor Ya-Ming Hou at Thomas Jefferson University, Philadelphia, USA. We explore tRNA epigenetic changes and how these changes control gene expression at the codon level and in response to cellular stress at the new frontier of molecular biology and the central dogma. We use a synthetic biology approach with CRISPR-edited genomes and CRISPRi approaches to determine how changes in tRNA epigenetics impact cell fitness in human health and disease. We have an intellectually stimulating environment and we encourage global networking. Current projects on tRNA epigenetic biology focus on:
(1) response to environmental stress
(2) discovery of new bacterial physiology and antibiotic therapeutics
(3) neurodegenerative and mitochondrial diseases
For more information, please see the following publications and our website:
Nat Communications (2021). PMID: 33436566
Candidates with a recent Ph.D. and a passion for basic research are encouraged to apply. Experience in molecular biology, enzymology, nucleic acids research, and protein purification and biotechnology is preferred.
Please send a cover letter, CV, and contact information of three references to:
RIKEN is currently accepting applications for the FY 2022 Special Postdoctoral Researcher (SPDR) Program, from young, creative, independent researchers who will be a powerful force in furthering RIKEN’s research activities.
Number of openings: Around 60
Salary and benefits (FY 2020 figures):
• Annual salary paid in monthly installments of 487,000 yen (gross amount).
• Commuting allowance (actual cost up to maximum of 55,000 yen per month)
• Housing allowance (partial payment of rent)
• Research budget: 1,000,000 yen per year
• Fixed-term contract employee (3 years)
Applications will be accepted from February 1 to April 15, 2021.
Postdoctoral Position in Mitochondrial Biology & electrophysiology
Dept. of Physiology, University of Maryland School of Medicine
The GargLab in the Department of Physiology at the University of Maryland Baltimore is seeking a highly motivated scientist with a strong background in molecular biology and/or electrophysiology to join our team. Research in the lab focuses on the molecular physiology of mitochondrial proteins specifically ion channels and transporters, their role in human disease, and how different organisms adapt to defects in mitochondrial functions. We use high resolution electrophysiological, imaging and biochemical approaches to elucidate signaling pathways that are fundamental to mitochondrial bioenergetics, using diverse model systems.
Dr. Vivek Garg