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Team Leader: Nicholas Parrish M.D., Ph.D.

Research Field:
The primary objective of this research team is to investigate the potential immunological functions of endogenous viral sequences found in mammalian genomes. Some of these sequences have been observed to produce small RNAs that are antisense relative to the viral transcript from which they were derived (Parrish et al., RNA 2015). We are testing the hypothesis that such small RNAs are involved in antiviral immunity via RNA interference. This is interdisciplinary research integrating virology, immunology, genomics, epigenetics, RNA biology, evolutionary biology, and developmental biology. In the broad sense, we are studying cellular and organismal genomic plasticity in response to environmental stimuli (Sudmant, Parrish et al., Nature. 2015; Parrish et al., Current Opinion in Microbiology. 2016), in particular exogenous nucleic acid information (Parrish et al., Cell. 2018), and are open to hosting postdoctoral fellows with diverse research interests compatible with these topics.

Description:
The primary project investigates the role of endogenous viral sequences in viral infection. The researcher will assist with generation, maintenance, infection, and postinfection assessment of genetically modified mice. The successful applicant will take advantage of the existing strengths of the Center for Integrative Medical Sciences’immunology (Divisions of Human Immunology, Cancer Immunology, and Disease Systems Biology) and genomics (Division of Genomic Medicine) programs via active collaboration.

For more information, please email nicholas.parrish@riken.jp
or visit
http://www.ims.riken.jp/labo/76/index.html

2019-01-07 2019-04-07

詳細・応募様式ダウンロード:http://www.tmgh.nagasaki-u.ac.jp/8215
Please download the Application-Guidance and complete the application form as instructed: http://www.tmgh.nagasaki-u.ac.jp/8215?lang=en

1. 研究分野および業務内容 Research Field and Position Information
長崎大学大学院 熱帯医学・グローバルヘルス(TMGH)研究科は,総合的アプローチにより世界の健康問題の解決をめざす「グローバルヘルス領域」での国際的研究を推進し,世界の健康改善に貢献し,国際的に活躍できる人材を養成することを目的としています。
Nagasaki University School of Tropical Medicine and Global Health (TMGH) was established in order to meet the pressing need to cultivate human resources who will solve global health challenges employing innovative, comprehensive, and transdisciplinary approaches.
この度,本研究科では,グローバルヘルス領域の教授候補者を選考することになり,以下の要件を有する方を1名,募集します。
TMGH is seeking a Professor in the area of Global Health who meets the following criteria;

① 疫学,生物統計学を中心としたアプローチ,社会科学や生物・社会人類学的アプローチ,環境保健学,保健政策,ヘルスシステム・マネジメントに関する専門分野において優れた研究・教育実績を有し,グローバルヘルス領域における教育・研究・実践を総合的に発展させることができる方の応募を期待しています。
The candidate will have an excellent track record of research and teaching experience with approaches centering on epidemiology and biostatistics, social science, biological and social anthropological approaches, environmental health, health policy and health systems management. The School welcomes candidates who have the willingness and abilities to contribute comprehensively to developing education, research and practical skills in the field of Global Health.

② 本研究科では,熱帯地域及びその他の広範な地域で国際共同研究をおこなっています。このため,選考においては国際共同研究で優れた実績を有することを重視します。
The School leads international collaborative research in extensive areas, which include tropical areas throughout the world. For this reason, special consideration will be given in the selection process to a candidate with outstanding research achievements in international collaboration projects.

③ 本研究科では,国際健康開発コースでグローバルヘルス領域における実務専門家の養成をおこなっていることから,同領域の実務面において優れた実績を有することを重視します。
The International Development Course of the School focuses on training experts in areas of global health. A candidate with highly proven practical skills and experience in the field of Global Health will be desirable.

④ 当該教授は,グローバルヘルスの研究・実践とともに,修士課程および博士課程の授業・セミナー・実習等の教育に関与し,修士研究や博士研究の指導教員を務めていただきます。なお,本研究科修士課程では,すべての授業を英語で実施しています。
The post will involve teaching, conducting seminars and practical sessions for both master’s and research(PhD) degree courses and supervising students with their research. All lectures are conducted in English at our School.

⑤ また教授会構成員として,研究科の運営に責任を持っていただきます。学内各種委員会等に出席いただくため,日本語が堪能な方を優先します。
The candidate will be a member of the TMGH Faculty Meeting and will be responsible for the management of the School. Participation in the internal various committees will be required; therefore, a candidate with proficiency in Japanese will be given priority in the selection process.
なお,長崎大学が国立国際医療研究センター(NCGM 住所:東京都新宿区戸山1丁目21-1)に設置したNCGMサテライトでの教育等も一部,担当していただきます。
In addition to teaching in Nagasaki, the post will also be partially responsible for teaching at our NCGM Satellite Campus at National Centre for Global Health and Medicine (NCGM) in Tokyo (Address: 1-21-1 Toyama Shingjuku-ku, Tokyo)

2. 職種 教授 Job title: Professor

3. 採用予定時期 平成31年4月以降
Start date (provisional): After April 2019

4. 提出書類 Required Documents

① 履歴書(適宜様式) 1部
Resume / curriculum vitae with photograph

② 業績目録(別紙様式1) 1部
Publications List (Attachment 1)

③ 競争的資金獲得状況(別紙様式2) 1部
Record of funding from competitive research funders (Attachment 2)

④ 学術論文の主なもの10編の別刷
Copies of major publications (maximum 10)

⑤ 本研究科に採用された時の抱負(A4 2枚以内,様式自由)
Future aspirations at Nagasaki University (free format, A4 size paper, 2 pages maximum)

⑥ 参考意見聴取候補者3名以内(所属,氏名,連絡先を記載してください)
Three references with their contact information (affiliation, name, telephone number)

5. 提出期限 平成31年1月15日(火)〔必着〕
Closing Date: Jan. 15, 2019 (Tuesday)

6. 提出先 〒852-8523 長崎市坂本1丁目12-4 長崎大学熱帯医学・グローバルヘルス研究科長 宛
Submit documents to:
Dean of School of Tropical Medicine and Global Health, Nagasaki University
〒852-8523, 1-12-4 Sakamoto, Nagasaki City, Nagasaki

※封筒には,「グローバルヘルス分野教授候補者応募書類在中」と朱書きし,簡易書留でご送付ください。

※Please write “Application documents for Professor position” in red and send it by recorded delivery

7. 問い合わせ先 長崎大学熱帯医学・グローバルヘルス研究科事務室
Enquiries: Nagasaki University School of Tropical Medicine and Global Health
Administrative Office
TEL: 095-819-7008 FAX: 095-819-7892 TEL: 81-95-819-7008 / FAX: 81-95-819-7892
E-mail: tmgh_jimu@ml.nagasaki-u.ac.jp

※本研究科の情報については,HP「http://www.tmgh.nagasaki-u.ac.jp/」をご覧ください。

※To learn more about TMGH please visit http://www.tmgh.nagasaki-u.ac.jp/

8. その他 Other

・国籍は問いませんが,選考の過程で,本研究科にお出でいただき,日本語または英語で講演,インタビューを実施する場合がありますので,あらかじめご承知おき願います。
Please note that all nationalities are welcome to apply for the post; however, you may be asked to give a lecture and attend an interview which will be held either in Japanese or English.

※長崎大学は,「男女共同参画社会基本法」の趣旨に則り,男女共同参画を推進しています。
「業績と能力」が同等であると認められる場合は,女性を積極的に採用します。

*Nagasaki University promotes the fair treatment of both women and men and fully complies with the government’s law against gender discrimination (“男女共同参画社会基本法”). In cases of equal qualifications and ability, the University actively hires women as part of our policy of affirmative action to encourage workplace gender balance.

2018-12-20 2019-01-15

The Srinivasan Lab at Oklahoma Medical Research Foundation (OMRF) studies lymphedema, a debilitating disease for which there is no cure. The lab uses state of the art technologies to dissect the roles of transcription factors and signaling molecules. We collaborate with numerous internationally recognized investigators thus offering career development opportunities for trainees. Please check our latest publications: Geng et al (2016) Dev Biol. (cover image) Jan 1;409(1):218-33, Cha et al (2016) Genes Dev. (cover image) June 16; 30: 1-16, and Cha et al (2018) Cell Reports (cover image) October 16; 25(3):571-584.
More information about our lab can be found at
https://omrf.org/researchfaculty/scientists/srinivasan-sathish/
We are recruiting highly motivated researchers who are interested in Cell biology and Biochemistry.

Required Qualifications
Ph.D., M.D., or Ph.D./M.D.,
Fresh graduates will be considered for postdoctoral fellowships, and more experienced researchers will be considered for the position of Staff Scientist. Salary of postdoctoral fellows is according to the stipulation of NIH. Salary of the Staff Scientist will be commensurate with experience. Only candidates with at least one first author publication in respected journals of Cell Biology or Biochemistry would be considered for the positions.
Please send CV, list of 3 references, reprints of publications and a brief summary of interests and career goals to Sathish-srinivasan@omrf.org.
OMRF is an independent, not-for-profit, biomedical research institute in Oklahoma City, USA. OMRF has been selected as one of the best research institutions for post-docs from 2011 to 2013 in the USA by The Scientist journal. Oklahoma City metropolitan area offers affordable housing, low cost of living, great public schools and numerous recreational activities. Additional information about OMRF can be found at https://omrf.org/.

2018-12-14 2019-06-14

The long-term objective of the Janknecht laboratory is to understand how dysregulation of Jumonji C domain-containing (JMJD) protein family members contributes to the initiation and progression of cancer and other illnesses, which may help to develop novel strategies of clinical treatment. Using biochemical, cellular and mouse models, we endeavor to elucidate how JMJD proteins modulate cellular function and influence the development of tumors and metabolic disorders.
Most of the JMJD proteins are epigenetic regulators and often possess the ability to demethylate lysine residues on histones. Also, they are involved in developmental processes, and several JMJD proteins are suspected to be oncoproteins or tumor suppressors. We have initiated studies on many of the 33 known human JMJD proteins and already identified various seminal interaction partners, thereby gaining insights into some of the molecular mechanisms of JMJD proteins.
Aside from demethylating histones, JMJD proteins have recently been found to hydroxylate proteins and to function as proteases. Moreover, it is now clear that quite a few JMJD proteins are localized within the cytoplasm, indicating roles for JMJD proteins beyond epigenetic regulation. Notably, several JMJD proteins are vastly understudied and we have focused on those and up to now created three corresponding knockout mice. Our preliminary analysis of these mouse models revealed phenotypes such as reduced cancer susceptibility, altered insulin resistance, circadian rhythm and developmental defects.
To study the mechanism of action of those JMJD proteins, how their function is modulated and why their dysregulation can be an underlying cause of disease, our laboratory is searching for highly motivated postdoctoral fellows with experience in molecular and cell biology. Our laboratory is located in a state-of-the-art research complex with multiple core facilities, is part of a campus with ~100 research groups, and is funded by the National Institutes of Health (NIH). If you are interested in joining us, please forward your application via email and provide contact information (including email address and phone number) of three references.

The University of Oklahoma is an EA/AA Institution (http://www.ou.edu/eoo/). Individuals with disabilities and protected veterans are encouraged to apply.

Contact Address
Ralf Janknecht, Ph.D.
Professor of Cell Biology
University of Oklahoma Health Sciences Center (OUHSC)
975 NE 10th Street, BRC-1464
Oklahoma City, OK 73104, USA
Phone: +1-405-2718001, extension 47420
Email: ralf-janknecht@ouhsc.edu

2018-11-02 2019-01-30