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The GargLab in the Department of Physiology at the University of Maryland Baltimore is seeking a highly motivated scientist with a strong background in molecular biology and/or electrophysiology to join our team. Research in the lab focuses on the molecular physiology of mitochondrial proteins specifically ion channels and transporters, their role in human disease, and how different organisms adapt to defects in mitochondrial functions. We use high resolution electrophysiological, imaging and biochemical approaches to elucidate signaling pathways that are fundamental to mitochondrial bioenergetics, using diverse model systems.
Available projects include detailed investigations into the structure-function studies of Mitochondrial Calcium Uniporter and related proteins.
Located in the Howard Hall, we have access to extensive core facilities. The environment within the Department is highly collaborative, and extensive career training and mentoring is available within the department and from the Office of Postdoctoral Scholars. The department faculty is internationally recognized for membrane excitability & associated (muscle, neurological and cardiovascular) disorders, and extensive opportunities are available for collaborations. Our group is also a part of BioMet - The Center for Biomedical Engineering and Technology at UMB, and has access to multiple imaging modalities.
We are seeking exceptional individuals, with a track record of impactful publications, to join our new and highly collaborative team. Relevant areas of expertise include strong electrophysiology and/or molecular biology skills, and a strong desire to make a career in mitochondrial biology or membrane excitability. Specific knowledge of any of these areas is less critical, however, than outstanding intellectual ability and strong research and quantitative skills. These individuals will work in collaboration with an outstanding group of scientists with long-standing track records in basic and translational research. This is an excellent opportunity to learn mitochondrial patch clamp and biology, and break new grounds with high impact publications.
Interested applicants should email directly to Dr. Vivek Garg at vgarg[at]som.umaryland.edu, with a cover letter and a detailed CV (with name of the referees).

Dr. Vivek Garg
Dept. of Physiology
660 W. Redwood Street
University of Maryland School of Medicine
Baltimore, MD 21201

2021-02-01 2021-05-01

Number of positions:
One Assistant Professor position (Division of Laboratory Animal Research, Advanced Research Support Center)

Place of work:
Shitsukawa, Toon-city, Ehime 791-0295, Japan
(Shigenobu Campus, Ehime University)
Ehime University Advanced Research Support Center was established in 2015 as a facility open for both inside and outside the university, with the aim of promoting shared use and managing equipment efficiently, as well as contributing to the progress of education and research in basic to applied science.

Qualifications:
Applicants must be enthusiastic about research and education and meet all the following requirements:

(1) Have a Ph.D. degree;

(2) Experience of support for animal experiments;

(3) Excellent research ability;

(4) Those who have research achievements using laboratory animal, especially for mouse genetic techniques with genome editing such as CRISPR/Cas9.

(5) Those who can take on new challenges and are passionate about support/ research / education.

(6) Those who can actively carry out joint research centered on animal experiments in cooperation with the current staff after joining the position.

Treatment:
A full-time tenure-track position for five years with an annual salary system.

Starting date:
June 1, 2021 or later

Application materials:
(Your own style is acceptable.)

(1) Curriculum Vitae: including an education/employment/society/award record with a photo, phone number and an email address

(2) Reverse-chronological list of research achievements in 5 categories (1. Original papers, 2. Review articles, 3. Presentations at international conferences, 4. Received external funds such as Grant-in-Aid for Scientific Research (KAKENHI) and research grants, 5. Others. In addition, if there are any notable achievements such as awards or acquisition of patents, please describe them.)

(3) Reprint of major theses: up to 5 volumes, photocopies acceptable.

(4) Summary of research achievements: up to 2 pages in A4.

(5) A motivation letter in 2 parts; one is about research and education, and the other is about support work at the center. (about 1 sheet of A4 paper for each)

(6) The contact information of two persons who can be referred to (they should be contacted during the hiring process) and a recommendation letter from one of them.

Submit all printed application materials of (1)~(6) by post.
Write on the envelope with “Application Documents for Advanced Research Support Center” in red, and send by recorded delivery mail.
The application documents will not be returned. The personal information stated in the application documents will be used only for selection and recruitment purposes.

Deadline for applications: March 12, 2021
(The deadline has been extended from December 18, 2020)

Address for submission:
Research Support, Research Support Division, Medical School Management Department Ehime University
Shitsukawa, Toon, Ehime 791-0295 Japan

Where to make contact:
Yuuki Imai
Professor, Division of Laboratory Animal Research, Advanced Research Support Center,
Ehime University
Shitsukawa, Toon-city, Ehime 791-0295, Japan
Email: y-imai[at]m.ehime-u.ac.jp

Selection process:

(1) Screening of the application documents

(2) Personal interview and open seminar presentation

After passing the screening of the documents, you will be requested to visit Ehime University for interview and seminar presentation.
Nationality of the applicants will not be considered.

Additional Information:

(1) Ehime University hiring is in compliance with the principles of the Basic Act for Gender Equal Society, and promotes various programs to develop diversity in the research environment.

•Career Support Program for Young Researchers:
Hiring research assistants for female or male researchers who are expecting to have babies or who are raising small children so that they can maintain and develop their research and careers.

•Research Assistance Program for Female Researchers:
Hiring research assistants for female researchers whose research activities are limited by childbirth, child-rearing, sickness or injury, care for family members, or administrative responsibilities at the university. The assistance will be provided either to the individual researchers or to the laboratory (or research group) they belong to, depending on the case.

•Dual Career Support Program:
A partial (cross) appointment system for the partners of Ehime University academic staff. Researchers who live/work separately from their partners (who are Ehime University employees) are employed on a cross-appointment basis and engage in research at Ehime University for a limited time period.

•Child Care Centers:
“Emika Kids” on Johoku Campus, and “Aiai Kids” in the University Hospital on Shigenobu Campus.
“Aiai Kids” also provides care for sick children.

•Care for School Children:
Provided during the spring, summer, and winter vacations. Also, after school programs are provided all year-round at “Aiai Kids.”

2021-01-13 2021-03-12

A postdoc opportunity is available to study hepatic fibrosis in the lab of Dr. Jennifer Chen, Assistant Professor, Department of Medicine, Division of Gastroenterology and Hepatology at University of California, San Francisco.

The lab studies novel mechanisms of hepatic stellate cell inactivation and fibrosis regression. The lab has identified and validated several antifibrotic targets using in vitro and in vivo models of hepatic fibrosis. Our group is involved in several exciting collaborations, including with medicinal chemists, to develop novel small molecule inhibitors to target these identified pathways.

Applicants should submit a brief statement [1] explaining their interest in the position, a curriculum vita [2] and the contact information of three references [3] by email directly to Dr. Jennifer Chen at Jennifer.Chen4[at]ucsf.edu

Recent Publications
1. Alsamman, S., Christenson, S. A., Yu, A., Ayad, N. M. E., Mooring, M. S., Segal, J. M., Hu, J. K.-H., Schaub, J. R., Ho, S. S., Rao, V., Marlow, M. M., Turner, S. M., Sedki, M., Pantano, L., Ghoshal, S., Ferreira, D. D. S., Ma, H.-Y., Duwaerts, C. C., Espanol-Suner, R., Wei, L., Newcomb, B., Mileva, I., Canals, D., Hannun, Y. A., Chung, R. T., Mattis, A. N., Fuchs, B. C., Tager, A. M., Yimlamai, D., Weaver, V. M., Mullen, A. C., Sheppard, D., Chen, J. Y. Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice. Sci. Transl. Med. 2020 Aug 19; 12:557. DOI: 10.1126/scitranslmed.aay8798
2. Chen JY, Newcomb B, Zhou C, Pondick JV, Ghoshal S, York S, Motola D, Coant N, Yi JK, Mao C, Tanabe KK, Bronova I, Berdyshev E, Fuchs B, Hannun Y, Chung RT, Mullen AC. Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells. Sci Rep. 2017;7:44867.
3. Chen JY, Ren Y, Yan P, Belina ME, Chung RT, Butt A. Tricyclic Antidepressant Use and the Risk of Fibrosis Progression in Hepatitis C-Infected Persons: Results from ERCHIVES. J Viral Hepat 2018; 25(7): 825-833.
4. Zhou C, York SR, Chen JY, Pondick JV, Motola DL, Chung RT, Mullen AC. Long noncoding RNAs expressed in human hepatic stellate cells form networks with extracellular matrix proteins. Genome Med. 2016;8(1):1-20.

DESIRED SKILLS AND EXPERIENCE The ideal candidate should have a PhD or equivalent degree in molecular biology or other related fields with a strong foundation in cell biology, biochemistry and mouse models of injury and fibrosis. The candidate should have strong publication record in international journals, possess good written and verbal communication skills, and be able to work independently and collaboratively within a research team. The candidate should be proficient in experimental mouse models and standard biological techniques (protein biochemistry, molecular biology, cell biology, tissue culture and pathology).

2021-01-06 2021-04-06

Institute for the Advanced Study of Human Biology (ASHBi) at Kyoto University is now looking for a Program-Specific Researcher (Postdoctoral Fellow) in Comparative Epigenomics of Bourque Group. For further details, please refer the following link of application requirements and guidelines.
URL: https://ashbi.kyoto-u.ac.jp/wp/wp-content/uploads/2020/12/201209_Postdoc_Bourque-G_ENG.pdf

Job Titles: Program-Specific Researcher (Postdoctoral Fellow)

Affiliation:
Institute for the Advanced Study of Human Biology (ASHBi), KUIAS Kyoto University
Yoshida Konoe-cho, Sakyo, Kyoto 606-8501 Japan

Eligibility:
Essential requirements are as follows:

1. The candidate has a Ph.D, or expected to have a Ph.D.

2. The candidate has excellent research achievements in the related fields and ability to develop and manage his/her research projects

3. He/she has communication skills in English

4. He/she has experiences of genomic experiments and next generation sequencing, or has enthusiasm to learn about these skills

Starting Date: April 1, 2021 or the earliest possible date thereafter (adjustable according to individual requirements)

Term: Max 5 years (Annual renewal).

Job Descriptions:
ASHBi will investigate the core concepts of human biology with a focus on genome regulation and disease modeling, creating a foundation of knowledge for developing innovative and unique human-centric therapies. The key goals are: 1) to achieve outstanding research in key individual themes in human biology in the area of reproduction, development, growth and aging as well as heredity and evolution; 2) to elucidate the principles for the emergence of species differences among humans, non-human primates, and rodents for proper extrapolation of the findings in model organisms to humans; 3) to generate primate models for key gene functions and intractable diseases; 4) to reconstitute key human cell lineages and tissues in vitro and validate their properties based on integrative information; and 5) to contribute to formalize an ethics for the use of human/non-human primate materials and create a philosophy to direct the values of the Institute’s research outcomes.
Comparative Epigenomics (Bourque’s Group) aims to understand human epigenome that underlies complex biological phenomena, such as cell differentiation, development, evolution and human diseases. To achieve this goal, we use cutting edge genomic technologies, such as RNA-seq, ChIP-seq, Cut&Tag, ATAC-seq and lentiMPRA, in combination with iPS cell and single-cell technologies. The candidate is expected to perform high-level research together with Dr. Fumitaka Inoue, co-PI of Bourque Group (for more detail see also; https://ashbi.kyoto-u.ac.jp/members/fumitaka-inoue/), and act as the leading researcher in human biology and the related fields.

Application Method:
Application documents must be prepared in English according to the “Application Guidelines”, and submitted as email attachments.
Submit via email to: ASHBi-recruit[at]mail2.adm.kyoto-u.ac.jp

2020-12-16 2021-03-16