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Outline
Graduate School of Frontier Biosciences at Osaka University is seeking outstanding applicants for a full professor position. We are looking for a candidate who develops prominent original research, demonstrates leadership both in Japan and overseas, and actively contributes to the education and management of the Graduate School of Frontier Biosciences. The position is open to all research areas related to life science, but we are particularly looking for a candidate working in neuroscience, cognitive science, theoretical biology, or information science. A successful candidate is expected to be involved in graduate education at the Graduate School of Frontier Biosciences, and undergraduate education at Biophysical Engineering Course of Faculty of Engineering Science.

Position   Professor

Number of Positions   1

Affiliation   Graduate School of Frontier Biosciences

Work Location
Graduate School of Frontier Biosciences
Suita Campus (1-3 Yamadaoka, Suita, Osaka, Japan)
School of Engineering Science
Toyonaka Campus (1-1 Machikaneyama-cho, Toyonaka, Osaka, Japan)

Specialized Field   Life science

Responsibilities
Educational activities for undergraduate and graduate school students (at Graduate School of Frontier Biosciences (Suita Campus) and School of Engineering Science (Toyonaka Campus))

Qualifications

Essential
A doctoral degree
Excellent research achievements in the related field/s

Desirable
Experience supervising students at the undergraduate and graduate levels

Starting Date   April 1, 2021 (negotiable)

Term of Employment   No Fixed Term (Until the end of the fiscal year at 65 years of age)

Probation Period   6 months

Employment Form
Based on "6. Regulations Pertaining to Working Hours, Holidays and Leave for National University Corporation Osaka University Staff"
https://www.osaka-u.ac.jp/en/guide/information/joho/kitei_shugyou.html

*The Discretionary Labor System, Special Work Type will be applied (deemed working hours: 8 hours a day)

Salary and Benefits
Based on "10. Salary Regulations for National University Corporation Osaka University Staff"
https://www.osaka-u.ac.jp/en/guide/information/joho/kitei_shugyou.html

Insurance
Medical insurance and employee's pension insurance of the Federation of National Public Service Personnel Mutual Aid Associations, Employment Insurance and Industrial Accident Compensation Insurance

Application Documents
Applications must be written in English or Japanese and include the following

A Curriculum Vitae

 *Please use the university form for educational/research positions available at the following website.
https://www.osaka-u.ac.jp/en/news/employ

A list of research achievements (original papers, review papers, books, patents, presentations at international conferences)

Reprints of 5 major original papers and their abstracts (photocopies acceptable)

A list and an outline of awards and prizes

An outline of research and education achievements (within two A4 pages)

A research plan and educational aspirations (within two A4 pages)

Name, affiliation, and contact information of two professional referees who are willing to be contacted

Reprints of most important papers (up to 5) and reviews (up to 2) in PDF format

*Personal information in the application documents will only be used for the purpose of screening and hiring procedures, and will not be disclosed to any third party.

*Submitted application documents will not be returned.

Sending Address and Contact Person

If submitted by postal service:
Attention: Professor Akihiko Ishijima
Graduate School of Frontier Biosciences, Osaka University
1-3 Yamadaoka, Suita-city, Osaka 565-0871 JAPAN

 *Please write "Application for professor in Graduate School of Frontier Biosciences" on the front of the envelope in red ink.

 *Applications should be sent by registered mail or courier.

If submitted by e-mail:
ishijima[at]fbs.osaka-u.ac.jp

 *Write "Application for professor in Graduate School of Frontier Biosciences" in the subject line.

 *Attach the application documents in PDF format (password protected).

 *Please send the password in a separate e-mail.

Contact Person:
Professor Akihiko Ishijima
Tel: +81-6-6879-4650
E-mail: ishijima[at]fbs.osaka-u.ac.jp

Application Deadline
March 31, 2020 (Japan Standard Time) or until the position is filled

Selection Process
Document screening will be followed by interviews. Selected applicants will be notified within two weeks after the application deadline.

*Travel and accommodation fees necessary for interviews are to be covered by the applicant. For applicants residing overseas, the applicant may request an online interview.

*Please note that unsuccessful applicants will not be contacted.

Additional Information
Concerning work conditions other than the above-mentioned, please refer to "3. Work Regulations for National University Corporation Osaka University Staff" and/or related regulations.
https://www.osaka-u.ac.jp/en/guide/information/joho/kitei_shugyou.html
Please note the above-mentioned work conditions are as of the day this employment offer is posted, and subject to change.
We welcome applications from highly motivated female candidates. Osaka University is committed to promoting gender equality and providing various supports for female academic staff members.
http://www.danjo.osaka-u.ac.jp/en_lp/

*Osaka University campuses and related facilities are smoke-free, except for designated areas.
Right after the appointment, successful applicant may form a new group of study and employ an associate professor (with a maximum employment term of 10 years). In addition, in or after December 2021, the applicant may employ an assistant professor (with a maximum employment term of 10 years). As well as the successful applicant, these faculty members will be responsible at Graduate School of Frontier Biosciences, for graduate level educational/research activities, and its management/administration, and as an academic member of School of Engineering Science, will also be responsible for undergraduate level educational/research activities, as well as the management/administration (entrance exams/committee activities).

Recruiter
National University Corporation Osaka University

2020-02-17 2020-03-31

Yoshihara laboratory will be opening in Lundquist Institute at Harbor UCLA Medical Center from Apr. 2020. We are interested in the origins of life/physiology and the molecular genetics of pancreatic islets, metabolic disease, inflammation (including autoimmune diseases and diabetes), and using this information to devise regenerative medicine and small-molecule therapy.

We are currently seeking a highly motivated postdoctoral fellow who is interested in the molecular basis of developmental biology and physiology and creating the novel therapeutics for type 1 and type 2 diabetes. The Yoshihara laboratory will use multi-omics analysis (genomics, metabolomics, proteomics), animal model and stem cells as the powerful tool to study diabetes and metabolism, and to identify therapeutic targets in metabolic diseases.

Experience in next-gen sequencing, mouse models, and/or stem cells is preferred but not required. Successful candidates will have or are in the final stages of completing a doctoral degree (Ph.D., M.D. /Ph.D., or M.D.), a track record of productivity with peer-reviewed publications, and excellent communication skills. Applicants should submit a cover letter, CV and contact information of 3 references to Eiji Yoshihara. eyoshihara@salk.edu (~3.31.2020) or eiji.yoshihara@lundquist.org (4.1.2020~). After the initial screening, Skype interview will be scheduled.

Qualifications:
Candidates must have a Ph.D., or equivalent doctoral degree in a field deemed relevant by the program.

Reference

1. Yoshihara E, Evans RM, Downs M, Yu RT, Atkins AR
”Compositions and methods for organoid generation and disease modeling”
United States; 17803511.9-1120 PCT/US2017034278; Publication Date 2019-03-04
Salk Institute for Biological studies (US Patent, 2019)

2. Fu T, Coulter S, Yoshihara E, Oh TG, Fang S, Cayabyab F, Zhu Q, Leblanc M, Gasser E, Liu S, Waizenegger W, He M, Atkins AR, Yu RT, Knight R, Liddle C, Downes M, Evans RM
FXR regulates intestinal cancer stem cell proliferation
(Cell 176, 1098-1112, 2019)

3. Wei Z, Yoshihara E, He N, Hah N, Fan W, Huddy T, Wang Y, Ross B, Dai Y, Ding N, Sherman MH, Fang S, Zhao X, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM
Vitamin D switches BAF complexes to protect β cells
(Cell 173, 1-15, 2018)

4. Ahmadian M, Liu S, Reilly SM, Hah N, Fan W, Yoshihara E, Jha P, De Magalhaes Filho CD, Jacinto S, Gomez AV, Dai Y, Yu RT, Liddle C, Atkins AR, Auwerx J, Saltiel AR, Downes M, Evans RM
ERRγ preserves Brown Fat Innate Thermogenic Activity
(Cell Reports 11, 2849-2859, 2018)

5. Yoshihara E, Wei Z, Lin CS, Fang S, Ahmadian M, Kida Y, Tseng T, Dai Y, Yu RT, Liddle C, Atkins A, Downes M, Evans RM
ERRγ is required for the metabolic maturation of therapeutically functional glucose responsive β cells
(Cell Metabolism 23,1-13 2016) Selected as Cell Metabolism, Best of 2016 paper

6. Kida YS, Kawamura T, Wei Z, Sogo T, Jacinto S, Shigeno A, Kushige H, Yoshihara E, Liddle C, Ecker JR, Yu RT, Atkins AR, Downes M, Evans RM.
ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency
(Cell Stem Cell, 6(5):547-55, 2015)

7. Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Dowens M, Evans RM
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
(Nature Medicine, doi: 10.1038/nm.3760, 2015)

8. Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefskey JM, Mohammadi M, Downes M, Evans RM
Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer
(Nature, doi:10.1038/nature13540, 2014)

9. Yoshihara E, Fujimoto S, Inagaki N, Okawa K, Masaki S, Yodoi J, Masutani H
Disruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity
(Nature Communications, 1:127 doi: 10.1038/ncomms1127, 2010)

10. Masters SL, Dunne A, Subramanian SL, Hull RL,Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll R, Mills KHG, Mok KH, Newsholme P, Nunez G, Yodoi J, Kahn SE, Lavelle EC, O’Neill LA.
Activation of the Nlrp3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type-2 diabetes
(Nature Immunology, 11(10):897-904, 2010)

2020-01-30 2020-04-30

Job title, available positions: Team Leader, one position

Research Field:
Whole genome analyses have become familiar along with innovations in the field of molecular biology. Our team has been using high-throughput DNA sequencing techniques to analyze gene mutations. LETmax mutants have become more and more useful and important in modern genetic studies, enabling the discovery of genes that control important traits, and revealing the functions and mechanisms underlying their operation. The discovery of genes using mutants may lead to emergence of a new field in biology, “mutagenomics”.

Job description:

• Development of efficient identification method of genomic mutations both computationally and experimentally

• Technical operation of genome analysis platform

• Analysis of genomic mutants induced by heavy-ion irradiations

• Evolutionary studies, epigenetics research and gene expression control research using chromosome structure change by beam irradiation

Deadline: 17:00(JST), March 31, 2020

Start of Employment: October 1, 2020 (Negotiable)

For more information, visit
https://www.riken.jp/en/careers/researchers/20200117/index.html

2020-01-22 2020-03-31

A postdoc opportunity is available to study hepatic fibrosis in the lab of Dr. Jennifer Chen, Assistant Professor, Department of Medicine, Division of Gastroenterology and Hepatology at University of California, San Francisco.

The lab studies novel mechanisms of hepatic stellate cell inactivation and fibrosis regression. The lab has identified and validated several antifibrotic targets using in vitro and in vivo models of hepatic fibrosis. The lab is also developing novel small molecule inhibitors to target these identified pathways.

Applicants should submit a brief statement [1] explaining their interest in the position, a curriculum vita [2] and the contact information of three references [3] by email directly to Dr. Jennifer Chen at Jennifer.Chen4@ucsf.edu

Recent Publications
1. Chen JY, Newcomb B, Zhou C, Pondick JV, Ghoshal S, York S, Motola D, Coant N, Yi JK, Mao C, Tanabe KK, Bronova I, Berdyshev E, Fuchs B, Hannun Y, Chung RT, Mullen AC. Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells. Sci Rep. 2017;7:44867.
2. Chen JY, Ren Y, Yan P, Belina ME, Chung RT, Butt A. Tricyclic Antidepressant Use and the Risk of Fibrosis Progression in Hepatitis C-Infected Persons: Results from ERCHIVES. J Viral Hepat 2018; 25(7): 825-833.
3. Zhou C, York SR, Chen JY, Pondick JV, Motola DL, Chung RT, Mullen AC. Long noncoding RNAs expressed in human hepatic stellate cells form networks with extracellular matrix proteins. Genome Med. 2016;8(1):1-20.

DESIRED SKILLS AND EXPERIENCE The ideal candidate should have a PhD or equivalent degree in molecular biology or other related fields with a strong foundation in cell biology, biochemistry and mouse models of injury and fibrosis. The candidate should have strong publication record in international journals, possess good written and verbal communication skills, and be able to work independently and collaboratively within a research team. The candidate should be proficient in experimental mouse models and standard biological techniques (protein biochemistry, molecular biology, cell biology, tissue culture and pathology).

2020-01-21 2020-04-21

A fully funded postdoctoral position is available in the laboratory of Dr. Myriam Labelle at St. Jude Children’s Research Hospital in Memphis, TN, USA. The Labelle laboratory studies the role of the microenvironment in cancer progression and metastasis, with major efforts dedicated to elucidating the molecular mechanisms by which blood platelets, granulocytes, and the extracellular matrix (ECM) cooperate to promote metastasis (Cancer Cell, 20(5):576-90, 2011; PNAS, 111(30):E3053-61, 2014). In recent work (EMBO J, 38(16):e101302, 2019), we discovered that WISP1, a factor secreted by tumor cells upon interactions with platelets, promotes metastasis by inducing collagen linearization in tumors. We are now interested in further understanding the molecular basis of platelet-tumor cells and WISP1-ECM interactions and how they can be targeted to prevent cancer metastasis and improve the survival of cancer patients. Current studies are conducted leveraging a wide array of model systems and techniques including novel mouse models of metastasis, patient-derived xenografts, in vitro co-culture systems, and advanced microscopy approaches.

We are looking for a highly motivated and organized individual to join our team. The applicant should have strong communication skills, the ability to work independentlyand as part of collaborative research efforts, and a strong desire to make a major contribution to the field of cancer metastasis.

St Jude Children's Research Hospital offers an outstanding research environment, state-of-the-art scientific resources and facilities, and a community of highly collaborative investigators.

Minimum Experience
Candidates should have recently earned or expect to earn a Ph.D. and have a strong background in molecular and cell biology. Experience in cancer metastasis or platelet biology research is preferred but not required.

Please send a cover letter describing research interests and accomplishments, CV and the names and addresses of three references to myriam.labelle@stjude.org.

2020-01-10 2020-04-10

Available Position:
Research Scientist, one person, full-time.

Our lab:
We want to develop new techniques to "see" something unknown, in order to understand biological systems and to contribute to medical science and our understanding of diseases. Especially, we are focusing on visualizing the distribution of cell states by accurate system-wide measurements with single molecule and/or single cell resolution. We are also developing a new system to study cell systems dynamics and to predict the cell fate by live imaging, cell manipulation, sequencing, etc. Biological targets may be development, differentiation, regeneration, immune system, etc.
Reference:
http://www.bdr.riken.jp/en/research/labs/shiroguchi-k/index.html

Job Descriptions:
A successful candidate will develop new method(s), including instruments, to measure parameters quantitatively from single cells, a few cells, or cells from tissues based on techniques of optical microscope, microfluidics, cell biology, and/or molecular biology, bioinformatics, machine learning, and will measure samples which are important in biology and medical sciences. Biological targets may be organoids, tissues, immune cells, etc, to study development, differentiation, regeneration, aging, immune system, etc.

Work location:
RIKEN Center for Biosystems Dynamics Research
6-2-3 Furuedai Suita Osaka 565-0874 Japan

Start of Employment:
Earlier is better (Negotiable)

Inquiries for research contents
Katsuyuki Shiroguchi
Email: katsuyuki.shiroguchi[at]riken.jp
Laboratory for Prediction of Cell Systems Dynamics RIKEN Center for Biosystems Dynamics Research

Details:https://www.riken.jp/en/careers/researchers/20190603/

2019-11-27 2020-02-27