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- 3 independent PI positions

- Work location: RIKEN BDR Kobe Campus (Kobe, Japan)

- Generous startup + funding

The RIKEN Center for Biosystems Dynamics Research (BDR) aims to understand the general principles of organismal temporal dynamics throughout the lifespan from birth to death, including aging. Our interdisciplinary approaches include imaging, multi-omics, theory, molecular biology, stem cell biology, organoids, and diverse animal models.

We are now seeking to recruit Team Leaders who aim to explore new fields of life cycle science. How organisms including humans control the transitions of life stages, and how they achieve long-term control across distinct life stages, are our keen interests. Topics include metabolic, epigenetic, and morphogenetic transitions in the life cycle, multi-organ interactions, stem cell-based tissue maintenance, transgenerational interactions (e.g. mother-to-fetal communication), aging, and any other topics that will potentially lead to conceptual advances in life cycle science. We encourage proposals using unprecedented interdisciplinary approaches, such as combinations of reconstructing organs, comparing diverse animal models and primates including human subjects, linking events at multiple scales from molecules and cells to tissues and organs, and taking advantage of any other cutting-edge technologies.

BDR provides early-career Team Leaders with an excellent environment for their independent research, including internationally competitive start-up packages and annual research funds as well as mentoring by experienced senior PIs. Team Leaders will have access to cutting-edge facilities including various animal models, mouse genome engineering, multi-scale imaging and omics, and to opportunities for active collaborations with medical institutions, industry, and affiliated graduate schools. For more information please visit the BDR website (https://www.bdr.riken.jp/en/index.html).

We are committed to promoting gender and international diversity in our Center and strongly encourage applications from female and non-Japanese scientists. The recruitment will remain open until three scientists, including one or more female scientists, are appointed. The working language for all discussions open to BDR members is English.

For more information and required application documents, please visit the application website:
https://www.riken.jp/en/careers/researchers/20200326/index.html

We will start reviewing applications received by June 30, 2020.

2020-04-02 2020-06-30

Postdoctoral positions are available with Professor Ya-Ming Hou at Thomas Jefferson University, Sidney Kimmel Medical College. We focus on tRNA epigenetic changes and explore their roles in gene expression at the codon level and in response to cellular stress, which are new concepts at the cutting edge of molecular biology and central dogma. We use a synthetic biology approach with CRISPR/Cas-edited genomes to determine how modifications in tRNA impact cell fitness at the codon level. Our lab is intellectually stimulating and encouraging global networking. Current projects are tRNA epigenetic biology:

In response to environmental stress
In discovery of new bacterial physiology and antibiotic therapeutics
In neurodegenerative diseases.

For more information, please see the following publications and our website:

Cell Systems, 8, 302-314 (2019). PMID: 30981730 (Featured in Faculty 1000 Prime)
Nucleic Acids Res. 46, e37 (2018). PMID: 29361055
Nucleic Acids Res. 45, 4081-4093 (2017). PMID: 27956502
PNAS 113, 15096-15101 (2016). PMID: 27849575 (Featured in PNAS commentary)
Nat Struct Mol Biol, 10, 941-948 (2016). PMID: 27571175. (Featured in Science)
Nature Communications, 6:7226 (2015). PMID: 26009254
Chem and Biol (Cell Press) 21, 1351-1360 (2014). PMID: 25219964
Nature 510, 507-511 (2014). PMID: 24919148 (Featured in Nature News and Views)
Nat. Communications. 2:329 (2011). PMID: 21629262

https://houlaboratory.com/research
https://www.jefferson.edu/university/research/researcher/researcher-faculty/hou-laboratory.html

Candidates with a recent Ph.D. and a passion for basic research are encouraged to apply. Experience in RNA-seq, high-throughput data analysis, fluorescence microscopy, cell culture, molecular biology, protein enzymology, nucleic acids research, and mitochondrial research is preferred.

Please send a cover letter, CV, and contact information of three references to:

Ya-Ming Hou
Professor of Biochemistry and Mol Biology
Thomas Jefferson University
233 S. 10th Street, BLSB 220
Philadelphia, PA 19107, USA
T: 215-503-4480

Email: ya-ming.hou[at]jefferson.edu
2020-04-01 2020-07-01

Outline
International Christian University (ICU) is a private and bilingual university that provides a first-class liberal arts education in a culturally and religiously diverse international community of students, faculty and staff. ICU’s educational mission is based on Christian and democratic principles. ICU has approximately 3,000 students and over 150 faculty members from Japan and overseas. The university is located on a wooded campus in the suburbs of Tokyo.

We are pleased to announce an open search for a full-time faculty position in Dept. of Natural Sciences with a particular focus on Biochemistry or Molecular Biology. The successful applicant is expected to teach general education, foundation, and area major courses in the College of Liberal Arts, as well as courses in the Graduate School.

Department/Program
Department of Natural Sciences (Biology major)

Rank & Title Associate Professor or Professor

Employment
Full-time

Term of Employment
Associate Professor & Professor: Employment until the mandatory retirement age of 65.

Employment Conditions

1.Salary: in accordance with ICU employment regulations

2.Allowances: available, in accordance with ICU employment regulations (e.g. commuting allowance)

3.Working hours: in accordance with ICU employment regulations

4.Social insurance: coverage by Promotion and Mutual Aid Corporation for Private Schools of Japan (PMAC), workers’ compensation, etc.

Number of Positions
1

Qualifications

1.Ph.D. or equivalent in Biochemistry or Molecular Biology or a related field is required.

2.Language of instruction: English (Knowledge of Japanese or willingness to learn Japanese is desirable.) or English and Japanese

3.Christian (of any denomination). In exceptional circumstances, a non-Christian who affirms ICU's Christian ideals and commits to realizing them may be considered.

Deadline for Applications
Applications and supporting materials must be submitted no later than 23:59 April 30, 2020 (JST).

Starting Date
April 1, 2021 or September 1, 2021

Application and Selection Process

1.Register your application online.
URL: https://business.form-mailer.jp/fms/32dd8b00118117

2.Submit all the application materials online as described below.

3.After documentary screening, short-listed candidates will be requested to give a lecture and will be interviewed.

Notification of Decision
Applicants will be notified of the outcome by email.

Application Materials

1.Curriculum Vitae

2.List of Academic Publications (Do not submit actual publications unless requested.)

3.Name and contact information of three academic referees and one church minister/leader who can testify to the applicant's commitment to Christianity. We will approach your referees as necessary. (In the case of non-Christian applicants, please include within your cover letter a statement on your affirmation of ICU's Christian ideals and your commitment to realizing them. In this case, a pastoral reference is not necessary.)

4.Cover letter describing why you are applying for the position.

URL for Uploading
https://www.dropbox.com/request/bwdH56tkJKiP5gf5cy1P

*ICU has a contract with Dropbox Education with high security.You do not need a Dropbox account to upload files. Ignore an email message automatically transmitted by Dropbox, notifying the completion of file uploading.

File requirements:

• Format: PDF

• Size: Less than 3 MB (per file)

• Combine the documents into one file if possible.

• File name :Family name_All (e.g. Smith_All)

*If it is not possible to combine the documents into one file, name the files as follows.
Family name_CV,
Family name_publication,
Family name_references,
Family name_coverletter

If online submission is not possible, please write to the contact person below.
Personal information will be treated with confidentiality.

Contact Address
3-10-2 Osawa, Mitaka-shi, Tokyo 181-8585, JAPAN

Contact Person
Prof. Tatsuo Nunoshiba

Position of Contact Person
Professor, Department of Natural Sciences

E-mail
molbio-search[at]icu.ac.jp

Additional Information
For inquiries, please contact the above e-mail address.

2020-03-19 2020-04-30

Outline
International Christian University (ICU) is a private and bilingual university that provides a first-class liberal arts education in a culturally and religiously diverse international community of students, faculty and staff. ICU’s educational mission is based on Christian and democratic principles. ICU has approximately 3,000 students and over 150 faculty members from Japan and overseas. The university is located on a wooded campus in the suburbs of Tokyo.

We are pleased to announce an open search for a full-time faculty position in Dept. of Natural Sciences with a particular focus on Cell Biology. The successful applicant is expected to teach general education, foundation, and area major courses in the College of Liberal Arts, as well as courses in the Graduate School.

Department/Program
Department of Natural Sciences (Biology major)

Rank & Title
Associate Professor or Professor

Employment
Full-time

Term of Employment
Associate Professor & Professor: Employment until the mandatory retirement age of 65.

Employment Conditions

1.Salary: in accordance with ICU employment regulations

2.Allowances: available, in accordance with ICU employment regulations (e.g. commuting allowance)

3.Working hours: in accordance with ICU employment regulations

4.Social insurance: coverage by Promotion and Mutual Aid Corporation for Private Schools of Japan (PMAC), workers’ compensation, etc.

Number of Positions
1

Qualifications

1.Ph.D. or equivalent in Cell Biology or a related field is required.

2.Language of instruction: English (Knowledge of Japanese or willingness to learn Japanese is desirable.) or English and Japanese

3.Christian (of any denomination). In exceptional circumstances, a non-Christian who affirms ICU's Christian ideals and commits to realizing them may be considered.

Deadline for Applications
Applications and supporting materials must be submitted no later than 23:59 April 30, 2020 (JST).

Starting Date
April 1, 2021 or September 1, 2021

Application and Selection Process

1.Register your application online.
https://business.form-mailer.jp/fms/2c1b8955118364

2.Submit all the application materials online as described below.

3.After documentary screening, short-listed candidates will be requested to give a lecture and will be interviewed.

Notification of Decision

Applicants will be notified of the outcome by email.

Application Materials

1.Curriculum Vitae

2.List of Academic Publications (Do not submit actual publications unless requested.)

3.Name and contact information of three academic referees and one church minister/leader who can testify to the applicant's commitment to Christianity. We will approach your referees as necessary. (In the case of non-Christian applicants, please include within your cover letter a statement on your affirmation of ICU's Christian ideals and your commitment to realizing them. In this case, a pastoral reference is not necessary.)

4.Cover letter describing why you are applying for the position.

URL for Uploading
https://www.dropbox.com/request/vpXvY4BGmkP5qSFgiaa2

*ICU has a contract with Dropbox Education with high security.
You do not need a Dropbox account to upload files. Ignore an email message automatically transmitted by Dropbox, notifying the completion of file uploading.

File requirements:

• Format : PDF

• Size : Less than 3 MB (per file)

• Combine the documents into one file if possible.

• File name : Family name_All (e.g. Smith_All)

*If it is not possible to combine the documents into one file, name the files as follows.
Family name_CV,
Family name_publication,
Family name_references,
Family name_coverletter

If online submission is not possible, please write to the contact person below.
Personal information will be treated with confidentiality.

Contact Address
3-10-2 Osawa, Mitaka-shi, Tokyo 181-8585, JAPAN

Contact Person
Prof. Tatsuo Nunoshiba
Position of Contact Person
Professor, Department of Natural Sciences

E-mail
cellbio-search[at]icu.ac.jp

Additional Information
For inquiries, please contact the above e-mail address.

2020-03-19 2020-04-30

RIKEN is currently accepting applications for the FY 2021 Special Postdoctoral Researcher (SPDR) Program, from young, creative, independent researchers who will be a powerful force in furthering RIKEN’s research activities.

Number of openings: Around 60

Research fields:
Mathematical Sciences (pure mathematics, applied mathematics, computer science, information science, artificial intelligence, etc.), Physics I (particle, nuclear, astrophysics, etc.), Physics II (condensed matter), Chemistry, Biology (cell biology, developmental biology, plant biology, structural biology, microbiology, imaging, measuring, etc.), Medical Science (brain science, psychology, immunology, oncology, genome science, etc.) and Engineering that relate to research being conducted at RIKEN.

Qualifications:
Capable of independent and responsible pursuit of a research topic. See SPDR website for details.

Salary and benefits (FY 2019 figures):

• Annual salary paid in monthly installments of 487,000 yen (gross amount).

• Commuting allowance (actual cost up to maximum of 55,000 yen per month)

• Housing allowance (partial payment of rent)

• Research budget: 1,000,000 yen per year

• Fixed-term contract employee (3 years)

Applications will be accepted from February 3 to April 16, 2020.

Inquiry:
SPDR Desk, Research Personnel Affairs Section, RIKEN
2-1 Hirosawa, Wako, Saitama 351-0198 Japan
Email: wakate@riken.jp
http://www.riken.jp/en/careers/programs/spdr/career2021/
Note: The provisions for this position are premised on RIKEN’s current budget and are subject to change with any change in the budget. Please check the website for details.

2020-03-05 2020-04-16

Yoshihara laboratory will be opening in Lundquist Institute at Harbor UCLA Medical Center from Apr. 2020. We are interested in the origins of life/physiology and the molecular genetics of pancreatic islets, metabolic disease, inflammation (including autoimmune diseases and diabetes), and using this information to devise regenerative medicine and small-molecule therapy.

We are currently seeking a highly motivated postdoctoral fellow who is interested in the molecular basis of developmental biology and physiology and creating the novel therapeutics for type 1 and type 2 diabetes. The Yoshihara laboratory will use multi-omics analysis (genomics, metabolomics, proteomics), animal model and stem cells as the powerful tool to study diabetes and metabolism, and to identify therapeutic targets in metabolic diseases.

Experience in next-gen sequencing, mouse models, and/or stem cells is preferred but not required. Successful candidates will have or are in the final stages of completing a doctoral degree (Ph.D., M.D. /Ph.D., or M.D.), a track record of productivity with peer-reviewed publications, and excellent communication skills. Applicants should submit a cover letter, CV and contact information of 3 references to Eiji Yoshihara. eyoshihara@salk.edu (~3.31.2020) or eiji.yoshihara@lundquist.org (4.1.2020~). After the initial screening, Skype interview will be scheduled.

Qualifications:
Candidates must have a Ph.D., or equivalent doctoral degree in a field deemed relevant by the program.

Reference

1. Yoshihara E, Evans RM, Downs M, Yu RT, Atkins AR
”Compositions and methods for organoid generation and disease modeling”
United States; 17803511.9-1120 PCT/US2017034278; Publication Date 2019-03-04
Salk Institute for Biological studies (US Patent, 2019)

2. Fu T, Coulter S, Yoshihara E, Oh TG, Fang S, Cayabyab F, Zhu Q, Leblanc M, Gasser E, Liu S, Waizenegger W, He M, Atkins AR, Yu RT, Knight R, Liddle C, Downes M, Evans RM
FXR regulates intestinal cancer stem cell proliferation
(Cell 176, 1098-1112, 2019)

3. Wei Z, Yoshihara E, He N, Hah N, Fan W, Huddy T, Wang Y, Ross B, Dai Y, Ding N, Sherman MH, Fang S, Zhao X, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM
Vitamin D switches BAF complexes to protect β cells
(Cell 173, 1-15, 2018)

4. Ahmadian M, Liu S, Reilly SM, Hah N, Fan W, Yoshihara E, Jha P, De Magalhaes Filho CD, Jacinto S, Gomez AV, Dai Y, Yu RT, Liddle C, Atkins AR, Auwerx J, Saltiel AR, Downes M, Evans RM
ERRγ preserves Brown Fat Innate Thermogenic Activity
(Cell Reports 11, 2849-2859, 2018)

5. Yoshihara E, Wei Z, Lin CS, Fang S, Ahmadian M, Kida Y, Tseng T, Dai Y, Yu RT, Liddle C, Atkins A, Downes M, Evans RM
ERRγ is required for the metabolic maturation of therapeutically functional glucose responsive β cells
(Cell Metabolism 23,1-13 2016) Selected as Cell Metabolism, Best of 2016 paper

6. Kida YS, Kawamura T, Wei Z, Sogo T, Jacinto S, Shigeno A, Kushige H, Yoshihara E, Liddle C, Ecker JR, Yu RT, Atkins AR, Downes M, Evans RM.
ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency
(Cell Stem Cell, 6(5):547-55, 2015)

7. Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Dowens M, Evans RM
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
(Nature Medicine, doi: 10.1038/nm.3760, 2015)

8. Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefskey JM, Mohammadi M, Downes M, Evans RM
Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer
(Nature, doi:10.1038/nature13540, 2014)

9. Yoshihara E, Fujimoto S, Inagaki N, Okawa K, Masaki S, Yodoi J, Masutani H
Disruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity
(Nature Communications, 1:127 doi: 10.1038/ncomms1127, 2010)

10. Masters SL, Dunne A, Subramanian SL, Hull RL,Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll R, Mills KHG, Mok KH, Newsholme P, Nunez G, Yodoi J, Kahn SE, Lavelle EC, O’Neill LA.
Activation of the Nlrp3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type-2 diabetes
(Nature Immunology, 11(10):897-904, 2010)

2020-01-30 2020-04-30

A postdoc opportunity is available to study hepatic fibrosis in the lab of Dr. Jennifer Chen, Assistant Professor, Department of Medicine, Division of Gastroenterology and Hepatology at University of California, San Francisco.

The lab studies novel mechanisms of hepatic stellate cell inactivation and fibrosis regression. The lab has identified and validated several antifibrotic targets using in vitro and in vivo models of hepatic fibrosis. The lab is also developing novel small molecule inhibitors to target these identified pathways.

Applicants should submit a brief statement [1] explaining their interest in the position, a curriculum vita [2] and the contact information of three references [3] by email directly to Dr. Jennifer Chen at Jennifer.Chen4@ucsf.edu

Recent Publications
1. Chen JY, Newcomb B, Zhou C, Pondick JV, Ghoshal S, York S, Motola D, Coant N, Yi JK, Mao C, Tanabe KK, Bronova I, Berdyshev E, Fuchs B, Hannun Y, Chung RT, Mullen AC. Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells. Sci Rep. 2017;7:44867.
2. Chen JY, Ren Y, Yan P, Belina ME, Chung RT, Butt A. Tricyclic Antidepressant Use and the Risk of Fibrosis Progression in Hepatitis C-Infected Persons: Results from ERCHIVES. J Viral Hepat 2018; 25(7): 825-833.
3. Zhou C, York SR, Chen JY, Pondick JV, Motola DL, Chung RT, Mullen AC. Long noncoding RNAs expressed in human hepatic stellate cells form networks with extracellular matrix proteins. Genome Med. 2016;8(1):1-20.

DESIRED SKILLS AND EXPERIENCE The ideal candidate should have a PhD or equivalent degree in molecular biology or other related fields with a strong foundation in cell biology, biochemistry and mouse models of injury and fibrosis. The candidate should have strong publication record in international journals, possess good written and verbal communication skills, and be able to work independently and collaboratively within a research team. The candidate should be proficient in experimental mouse models and standard biological techniques (protein biochemistry, molecular biology, cell biology, tissue culture and pathology).

2020-01-21 2020-04-21

A fully funded postdoctoral position is available in the laboratory of Dr. Myriam Labelle at St. Jude Children’s Research Hospital in Memphis, TN, USA. The Labelle laboratory studies the role of the microenvironment in cancer progression and metastasis, with major efforts dedicated to elucidating the molecular mechanisms by which blood platelets, granulocytes, and the extracellular matrix (ECM) cooperate to promote metastasis (Cancer Cell, 20(5):576-90, 2011; PNAS, 111(30):E3053-61, 2014). In recent work (EMBO J, 38(16):e101302, 2019), we discovered that WISP1, a factor secreted by tumor cells upon interactions with platelets, promotes metastasis by inducing collagen linearization in tumors. We are now interested in further understanding the molecular basis of platelet-tumor cells and WISP1-ECM interactions and how they can be targeted to prevent cancer metastasis and improve the survival of cancer patients. Current studies are conducted leveraging a wide array of model systems and techniques including novel mouse models of metastasis, patient-derived xenografts, in vitro co-culture systems, and advanced microscopy approaches.

We are looking for a highly motivated and organized individual to join our team. The applicant should have strong communication skills, the ability to work independentlyand as part of collaborative research efforts, and a strong desire to make a major contribution to the field of cancer metastasis.

St Jude Children's Research Hospital offers an outstanding research environment, state-of-the-art scientific resources and facilities, and a community of highly collaborative investigators.

Minimum Experience
Candidates should have recently earned or expect to earn a Ph.D. and have a strong background in molecular and cell biology. Experience in cancer metastasis or platelet biology research is preferred but not required.

Please send a cover letter describing research interests and accomplishments, CV and the names and addresses of three references to myriam.labelle@stjude.org.

2020-01-10 2020-04-10