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Job title, available positions: Team Leader, one position

Research Field:
Whole genome analyses have become familiar along with innovations in the field of molecular biology. Our team has been using high-throughput DNA sequencing techniques to analyze gene mutations. LETmax mutants have become more and more useful and important in modern genetic studies, enabling the discovery of genes that control important traits, and revealing the functions and mechanisms underlying their operation. The discovery of genes using mutants may lead to emergence of a new field in biology, “mutagenomics”.

Job description:

• Development of efficient identification method of genomic mutations both computationally and experimentally

• Technical operation of genome analysis platform

• Analysis of genomic mutants induced by heavy-ion irradiations

• Evolutionary studies, epigenetics research and gene expression control research using chromosome structure change by beam irradiation

Deadline: 17:00(JST), March 31, 2020

Start of Employment: October 1, 2020 (Negotiable)

For more information, visit
https://www.riken.jp/en/careers/researchers/20200117/index.html

2020-01-22 2020-03-31

A postdoc opportunity is available to study hepatic fibrosis in the lab of Dr. Jennifer Chen, Assistant Professor, Department of Medicine, Division of Gastroenterology and Hepatology at University of California, San Francisco.

The lab studies novel mechanisms of hepatic stellate cell inactivation and fibrosis regression. The lab has identified and validated several antifibrotic targets using in vitro and in vivo models of hepatic fibrosis. The lab is also developing novel small molecule inhibitors to target these identified pathways.

Applicants should submit a brief statement [1] explaining their interest in the position, a curriculum vita [2] and the contact information of three references [3] by email directly to Dr. Jennifer Chen at Jennifer.Chen4@ucsf.edu

Recent Publications
1. Chen JY, Newcomb B, Zhou C, Pondick JV, Ghoshal S, York S, Motola D, Coant N, Yi JK, Mao C, Tanabe KK, Bronova I, Berdyshev E, Fuchs B, Hannun Y, Chung RT, Mullen AC. Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells. Sci Rep. 2017;7:44867.
2. Chen JY, Ren Y, Yan P, Belina ME, Chung RT, Butt A. Tricyclic Antidepressant Use and the Risk of Fibrosis Progression in Hepatitis C-Infected Persons: Results from ERCHIVES. J Viral Hepat 2018; 25(7): 825-833.
3. Zhou C, York SR, Chen JY, Pondick JV, Motola DL, Chung RT, Mullen AC. Long noncoding RNAs expressed in human hepatic stellate cells form networks with extracellular matrix proteins. Genome Med. 2016;8(1):1-20.

DESIRED SKILLS AND EXPERIENCE The ideal candidate should have a PhD or equivalent degree in molecular biology or other related fields with a strong foundation in cell biology, biochemistry and mouse models of injury and fibrosis. The candidate should have strong publication record in international journals, possess good written and verbal communication skills, and be able to work independently and collaboratively within a research team. The candidate should be proficient in experimental mouse models and standard biological techniques (protein biochemistry, molecular biology, cell biology, tissue culture and pathology).

2020-01-21 2020-04-21

A fully funded postdoctoral position is available in the laboratory of Dr. Myriam Labelle at St. Jude Children’s Research Hospital in Memphis, TN, USA. The Labelle laboratory studies the role of the microenvironment in cancer progression and metastasis, with major efforts dedicated to elucidating the molecular mechanisms by which blood platelets, granulocytes, and the extracellular matrix (ECM) cooperate to promote metastasis (Cancer Cell, 20(5):576-90, 2011; PNAS, 111(30):E3053-61, 2014). In recent work (EMBO J, 38(16):e101302, 2019), we discovered that WISP1, a factor secreted by tumor cells upon interactions with platelets, promotes metastasis by inducing collagen linearization in tumors. We are now interested in further understanding the molecular basis of platelet-tumor cells and WISP1-ECM interactions and how they can be targeted to prevent cancer metastasis and improve the survival of cancer patients. Current studies are conducted leveraging a wide array of model systems and techniques including novel mouse models of metastasis, patient-derived xenografts, in vitro co-culture systems, and advanced microscopy approaches.

We are looking for a highly motivated and organized individual to join our team. The applicant should have strong communication skills, the ability to work independentlyand as part of collaborative research efforts, and a strong desire to make a major contribution to the field of cancer metastasis.

St Jude Children's Research Hospital offers an outstanding research environment, state-of-the-art scientific resources and facilities, and a community of highly collaborative investigators.

Minimum Experience
Candidates should have recently earned or expect to earn a Ph.D. and have a strong background in molecular and cell biology. Experience in cancer metastasis or platelet biology research is preferred but not required.

Please send a cover letter describing research interests and accomplishments, CV and the names and addresses of three references to myriam.labelle@stjude.org.

2020-01-10 2020-04-10

Available Position:
Research Scientist, one person, full-time.

Our lab:
We want to develop new techniques to "see" something unknown, in order to understand biological systems and to contribute to medical science and our understanding of diseases. Especially, we are focusing on visualizing the distribution of cell states by accurate system-wide measurements with single molecule and/or single cell resolution. We are also developing a new system to study cell systems dynamics and to predict the cell fate by live imaging, cell manipulation, sequencing, etc. Biological targets may be development, differentiation, regeneration, immune system, etc.
Reference:
http://www.bdr.riken.jp/en/research/labs/shiroguchi-k/index.html

Job Descriptions:
A successful candidate will develop new method(s), including instruments, to measure parameters quantitatively from single cells, a few cells, or cells from tissues based on techniques of optical microscope, microfluidics, cell biology, and/or molecular biology, bioinformatics, machine learning, and will measure samples which are important in biology and medical sciences. Biological targets may be organoids, tissues, immune cells, etc, to study development, differentiation, regeneration, aging, immune system, etc.

Work location:
RIKEN Center for Biosystems Dynamics Research
6-2-3 Furuedai Suita Osaka 565-0874 Japan

Start of Employment:
Earlier is better (Negotiable)

Inquiries for research contents
Katsuyuki Shiroguchi
Email: katsuyuki.shiroguchi[at]riken.jp
Laboratory for Prediction of Cell Systems Dynamics RIKEN Center for Biosystems Dynamics Research

Details:https://www.riken.jp/en/careers/researchers/20190603/

2019-11-27 2020-02-27