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The long-term objective of the Janknecht laboratory is to understand how dysregulation of Jumonji C domain-containing (JMJD) protein family members contributes to the initiation and progression of cancer and other illnesses, which may help to develop novel strategies of clinical treatment. Using biochemical, cellular and mouse models, we endeavor to elucidate how JMJD proteins modulate cellular function and influence the development of tumors and metabolic disorders.
Most of the JMJD proteins are epigenetic regulators and often possess the ability to demethylate lysine residues on histones. Also, they are involved in developmental processes, and several JMJD proteins are suspected to be oncoproteins or tumor suppressors. We have initiated studies on many of the 33 known human JMJD proteins and already identified various seminal interaction partners, thereby gaining insights into some of the molecular mechanisms of JMJD proteins.
Aside from demethylating histones, JMJD proteins have recently been found to hydroxylate proteins and to function as proteases. Moreover, it is now clear that quite a few JMJD proteins are localized within the cytoplasm, indicating roles for JMJD proteins beyond epigenetic regulation. Notably, several JMJD proteins are vastly understudied and we have focused on those and up to now created three corresponding knockout mice. Our preliminary analysis of these mouse models revealed phenotypes such as reduced cancer susceptibility, altered insulin resistance, circadian rhythm and developmental defects.
To study the mechanism of action of those JMJD proteins, how their function is modulated and why their dysregulation can be an underlying cause of disease, our laboratory is searching for highly motivated postdoctoral fellows with experience in molecular and cell biology. Our laboratory is located in a state-of-the-art research complex with multiple core facilities, is part of a campus with ~100 research groups, and is funded by the National Institutes of Health (NIH). If you are interested in joining us, please forward your application via email and provide contact information (including email address and phone number) of three references.

The University of Oklahoma is an EA/AA Institution (http://www.ou.edu/eoo/). Individuals with disabilities and protected veterans are encouraged to apply.

Contact Address
Ralf Janknecht, Ph.D.
Professor of Cell Biology
University of Oklahoma Health Sciences Center (OUHSC)
975 NE 10th Street, BRC-1464
Oklahoma City, OK 73104, USA
Phone: +1-405-2718001, extension 47420
Email: ralf-janknecht@ouhsc.edu

2018-11-02 2019-01-30

The Park Lab is seeking a highly motivated postdoc to study synaptic molecular mechanisms of learning and memory. Candidates with expertise/interest in molecular biology, biochemistry, live cell imaging, histology, and/or animal behavior are particularly encouraged to apply. The start date is negotiable, but January 2019 is preferred. If you would like to join our lab, please send a CV and a brief statement of research interests and experience to joongkyu.park@wayne.edu by November 11, 2018.

Joongkyu Park, Ph.D.
Assistant Professor of Pharmacology and Neurology
Wayne State University School of Medicine
joongkyu.park@wayne.edu
www.synapsepark.com

2018-10-29 2018-11-11

The RIKEN Center for Brain Science (CBS) is Japan's premier neuroscience research center that builds on the twenty years of research achievements of its predecessor, the RIKEN Brain Science Institute (BSI). Taking advantage of the multidisciplinarity of the fields of medicine, biology, chemistry, engineering, mathematical sciences, and psychology, our aim is to advance basic research on the functions of the brain and the mind—from the levels of single cells and whole organisms to societal systems—and develop innovative technologies in the process. We also aim to find solutions to the issues confronting contemporary society, as we grapple with the psychological ramifications of our own inventions such as artificial intelligence (AI) and big data, and as we seek to conquer diseases such as depression and dementia.

For details, please refer to the RIKEN CBS website. https://cbs.riken.jp/en/

Now we are newly seeking outstanding neuroscientists for tenure-track Team Leader positions (equivalent to U.S. Assistant or Associate Professors). However, exceptional applications from internationally established neuroscientists may be considered for tenured Team Leader positions (equivalent to U.S. Full Professors). This is our first round of faculty recruitment at CBS, and in the coming several years CBS plans to open approximately 10 new Team Leader positions for outstanding neuroscientists.
At RIKEN CBS, Team Leaders have full intellectual independence, generous internal funds including a highly competitive start-up package and access to ample communal facilities in a collaborative environment. Successful candidates for the Team Leader position must have demonstrated the ability to develop an original, independent and internationally competitive research program.
We encourage applications from all disciplines of neuroscience at the molecular, cellular, circuit, systems and/or cognitive levels using any model animals and/or involving human subjects. Neuroscientists with research interests in psychiatric/neurological diseases or computational/theoretical approaches are also encouraged to apply.
Applications received by the end of November 2018 will be screened in the first round of review, although the call will remain open until the positions are filled.

Required documents (All documents including letters of recommendation should be written in English)

1. A cover letter with a brief summary of the current research program and future plan

2. Complete CV (with photo, home address, telephone number, email address, work history, academic degrees, current affiliation and position, certifications, etc.) Please write the number (W18032) next to the title of this job posting in the upper right corner of your CV.

3. List of research achievements and publications (separate by category: research papers, review papers, patents, etc.)

4. Current research and achievements to date

5. Future research plans

6. Reprints of major research papers you authored (maximum five papers); circle these paper titles in the list of research achievement and publications above (item 3).

7. Three letters of recommendation (including one from the current supervisor, if available.) Please arrange to have the recommendation letters sent directly from referees to the CBS Search Committee address (see below) as a PDF document prepared as follows:

NB1: Letters of recommendation must be signed (or stamped) by the person writing the letter.

NB2: Letters must be addressed to “Director Yasushi Miyashita, RIKEN Center for Brain Science”.

NB3: If current supervisor's recommendation is not available, a recommendation letter from a third party will be accepted.

NB4: The applicant should inform us (CBS Search Committee) of the referee's title and position, affiliation, telephone number, email address and relationship between the applicant.

In addition to the items 1 to 7 above, during the hiring procedures for successful candidates, a check sheet and a Confirmation of employment duration and duties form and documents for obtaining a work visa for non-Japanese nationals will be required.

Application Submission
Send your application as a PDF document by email to cbs-search[at]ml.riken.jp (Replace [at] with @). Referees must directly send letters of recommendation by email (attached with a letter of recommendation with signature (or stamp) in PDF format), to the same address.

Details: https://cbs.riken.jp/en/careers/open_faculty_positions

RIKEN CBS is located just outside of the international metropolis of Tokyo. English is the primary language used in activities at CBS, including seminars and administration. Institutional support is available to help non-Japanese speaking scientists, whom we particularly encourage to apply. RIKEN Center for Brain Science is an Equal Opportunity Employer. Women are strongly encouraged to apply.
For further inquiries please contact the RIKEN CBS Search Committee <cbs-search@ml.riken.jp>.

2018-10-04 2018-11-30

A postdoctoral position is open in the area of molecular pathogenesis of age-related diseases at Northwestern University School of Medicine in Chicago, USA. [Yuasa-Kawada et al, Nature Neuroscience 12:1087-1089; Yuasa-Kawada et al., Proc Natl Acad Sci USA 106:14530-14535; Li et al, Proc Natl Acad Sci USA 107:3169-3174; Guo W, et al, Nature Structural & Mol Biol 18:822–830; Zhu et al., Hum Mol Genet. 23(25):6863-77; Deng et al., PloSGenetics 2015 Sep 3;11(9):e1005357; Kong et al., J Clinical Investigation 125(12):4407-4420; Deng J et al, 2018, Proc Natl Acad Sci USA In press].
Applicants may send a brief summary of past accomplishment and curriculum vitae by email to Professor Jane Wu (jane-wu@northwestern.edu)

2018-09-27 2018-12-27