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The Srinivasan Lab at Oklahoma Medical Research Foundation (OMRF) studies lymphedema, a debilitating disease for which there is no cure. The lab uses state of the art technologies to dissect the roles of transcription factors and signaling molecules. We collaborate with numerous internationally recognized investigators thus offering career development opportunities for trainees. Please check our latest publications: Geng et al (2016) Dev Biol. (cover image) Jan 1;409(1):218-33, Cha et al (2016) Genes Dev. (cover image) June 16; 30: 1-16, and Cha et al (2018) Cell Reports (cover image) October 16; 25(3):571-584.
More information about our lab can be found at
https://omrf.org/researchfaculty/scientists/srinivasan-sathish/
We are recruiting highly motivated researchers who are interested in Cell biology and Biochemistry.

Required Qualifications
Ph.D., M.D., or Ph.D./M.D.,
Fresh graduates will be considered for postdoctoral fellowships, and more experienced researchers will be considered for the position of Staff Scientist. Salary of postdoctoral fellows is according to the stipulation of NIH. Salary of the Staff Scientist will be commensurate with experience. Only candidates with at least one first author publication in respected journals of Cell Biology or Biochemistry would be considered for the positions.
Please send CV, list of 3 references, reprints of publications and a brief summary of interests and career goals to Sathish-srinivasan@omrf.org.
OMRF is an independent, not-for-profit, biomedical research institute in Oklahoma City, USA. OMRF has been selected as one of the best research institutions for post-docs from 2011 to 2013 in the USA by The Scientist journal. Oklahoma City metropolitan area offers affordable housing, low cost of living, great public schools and numerous recreational activities. Additional information about OMRF can be found at https://omrf.org/.

2018-12-14 2019-06-14

The long-term objective of the Janknecht laboratory is to understand how dysregulation of Jumonji C domain-containing (JMJD) protein family members contributes to the initiation and progression of cancer and other illnesses, which may help to develop novel strategies of clinical treatment. Using biochemical, cellular and mouse models, we endeavor to elucidate how JMJD proteins modulate cellular function and influence the development of tumors and metabolic disorders.
Most of the JMJD proteins are epigenetic regulators and often possess the ability to demethylate lysine residues on histones. Also, they are involved in developmental processes, and several JMJD proteins are suspected to be oncoproteins or tumor suppressors. We have initiated studies on many of the 33 known human JMJD proteins and already identified various seminal interaction partners, thereby gaining insights into some of the molecular mechanisms of JMJD proteins.
Aside from demethylating histones, JMJD proteins have recently been found to hydroxylate proteins and to function as proteases. Moreover, it is now clear that quite a few JMJD proteins are localized within the cytoplasm, indicating roles for JMJD proteins beyond epigenetic regulation. Notably, several JMJD proteins are vastly understudied and we have focused on those and up to now created three corresponding knockout mice. Our preliminary analysis of these mouse models revealed phenotypes such as reduced cancer susceptibility, altered insulin resistance, circadian rhythm and developmental defects.
To study the mechanism of action of those JMJD proteins, how their function is modulated and why their dysregulation can be an underlying cause of disease, our laboratory is searching for highly motivated postdoctoral fellows with experience in molecular and cell biology. Our laboratory is located in a state-of-the-art research complex with multiple core facilities, is part of a campus with ~100 research groups, and is funded by the National Institutes of Health (NIH). If you are interested in joining us, please forward your application via email and provide contact information (including email address and phone number) of three references.

The University of Oklahoma is an EA/AA Institution (http://www.ou.edu/eoo/). Individuals with disabilities and protected veterans are encouraged to apply.

Contact Address
Ralf Janknecht, Ph.D.
Professor of Cell Biology
University of Oklahoma Health Sciences Center (OUHSC)
975 NE 10th Street, BRC-1464
Oklahoma City, OK 73104, USA
Phone: +1-405-2718001, extension 47420
Email: ralf-janknecht@ouhsc.edu

2018-11-02 2019-01-30

A postdoctoral position is open in the area of molecular pathogenesis of age-related diseases at Northwestern University School of Medicine in Chicago, USA. [Yuasa-Kawada et al, Nature Neuroscience 12:1087-1089; Yuasa-Kawada et al., Proc Natl Acad Sci USA 106:14530-14535; Li et al, Proc Natl Acad Sci USA 107:3169-3174; Guo W, et al, Nature Structural & Mol Biol 18:822–830; Zhu et al., Hum Mol Genet. 23(25):6863-77; Deng et al., PloSGenetics 2015 Sep 3;11(9):e1005357; Kong et al., J Clinical Investigation 125(12):4407-4420; Deng J et al, 2018, Proc Natl Acad Sci USA In press].
Applicants may send a brief summary of past accomplishment and curriculum vitae by email to Professor Jane Wu (jane-wu@northwestern.edu)

2018-09-27 2018-12-27