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The Posfai Lab (www.posfailab.org) at Princeton University is looking to recruit a highly motivated postdoctoral fellow. Our group studies the molecular and cellular mechanisms of cell fate choice and morphogenesis during early embryonic development, using the preimplantation mouse embryo as a model system. Our main approach is combining genetic engineering and quantitative, high-resolution live imaging using light sheet microscopy. The lab’s assets include our recently developed highly efficient genome editing method in mouse embryos and our own light sheet microscope dedicated to preimplantation embryo imaging.

The postdoctoral candidate should have a strong interest in developmental biology and mouse genetics. Experience in light sheet microscopy and/or computational image analysis is preferred, but not necessary. Motivation and excellence is valued more than previous field of study.

The candidate will benefit from an interdisciplinary and collaborative environment at Princeton and the vibrant and supportive atmosphere of a junior lab. Researchers at the rank of Postdoctoral Research Associate are ordinarily appointed for one year at a time. Appointments are reviewed annually to consider reappointment and salary level. The position is benefits-eligible.

To apply, email your CV and cover letter explaining your interests and motivation to Eszter Posfai (eposfai@princeton.edu) and arrange for three reference letters to be sent on your behalf.

For more information, visit www.posfailab.org.

2019-02-22 2019-05-22

The Kojima Lab is looking for a highly motivated Postdoctoral Associate to work on a NIH-funded project that dissects molecular functions of a novel non-coding gene in the mammalian circadian system. We are looking for ambitious, creative and smart colleagues, whose expertise enriches our team.

Required Qualifications include: 1) Ph.D. degree in biochemistry, biology, or a related field, 2) One or more publication as a first-author in a peer-reviewed journal, 3) Experience in at least one of the following fields (molecular/cellular biology, generation of genetically modified animal models, RNA biology). Experiences in bioinformatics and/or mathematical modeling of molecular regulatory networks will be appreciated.

This position carries a salary of $45,000 – $58,850 (depending on experience) plus benefits, including health insurance. Review of applications will begin immediately until the positions are filled. To apply, please submit a cover letter discussing your interest in a position, your curriculum vitae, a half-page research statement, and contact information for three references at: https://listings.jobs.vt.edu/postings/94635

Further inquiries should be directed to Shihoko Kojima (skojima@vt.edu). Our laboratory is committed to promoting diversity and inclusion at Virginia Tech, and we welcome applications by individuals with disabilities, or members of minorities or other disadvantaged groups.

2019-02-15 2019-05-15

The Thymus Biology Section in the Experimental Immunology Branch, CCR, NCI, NIH, focuses on the mechanisms how the thymic microenvironments contribute to the development of functionally potent and self-tolerant T cells. We are particularly interested in studying how the diversity in thymic epithelial cells develops, how thymic epithelial cell subpopulations contribute to functional-tuning and self-tolerance in T cells, and how the thymic microenvironments sequentially guide the position of developing T cells to optimize their development and selection. Unveiling the thymic machinery in these processes will aid future therapies.

Our recent contributions include: Murata et al. Nat Immunol. 2018; Sakata et al. J Immunol. 2018; Kozai et al. J Exp Med. 2017; Ohigashi et al. JCI Insight. 2017; Uddin et al. Nat Commun. 2017; Takahama et al. Nat Rev Immunol. 2017; Ohigashi et al. Cell Rep. 2015; Takada et al. Nat Immunol. 2015; and Sasaki et al. Nat Commun. 2015.

We look for a self-motivated and enthusiastic scientist with a recent Ph.D. or M.D. Experience in immunology, developmental biology, and molecular biology is desirable.

Interested applicants should send a curriculum vitae, the names of three references, and a brief summary of their previous research and future goals to yousuke.takahama@nih.gov. Review of applications will begin immediately and continue until the position is filled.

Yousuke Takahama, Ph.D.
Senior Investigator
Thymus Biology Section
Experimental Immunology Branch
Center for Cancer Research
National Cancer Institute
National Institutes of Health
Building 10 Room 4B10
Bethesda, Maryland 20892
Phone: 240-858-3223
Email: yousuke.takahama@nih.gov
https://ccr.cancer.gov/Experimental-Immunology-Branch/yousuke-takahama

2019-02-05 2019-05-05

A postdoctoral position available in the Shcheglovitov Lab at the University of Utah to study the biochemical and functional properties of human neurons and organoids derived from patient-specific and CRISPR/Cas9-engineered induced pluripotent stem cells for modeling autism, intellectual disability, and epilepsy. We particularly invite applications from ambitious, exquisite, and motivated individuals with substantial neuroscience-related experience in molecular biology, biochemistry, physiology, or imaging. The work in our lab is currently centered around two NIH-funded research projects:

Project 1: Cellular and molecular mechanisms disrupted in 22q13 deletion syndrome and autism. We previously demonstrated that SHANK3-deficient human cortical neurons derived from induced pluripotent stem cells (iPSCs) acquired from 22q13 deletion syndrome patients with autism and intellectual disability have severely impaired excitatory synaptic transmission (Shcheglovitov et al., Nature 2013). However, the cellular and molecular mechanisms responsible for the development of these deficits remain unknown. The main goal of this project is to elucidate the cellular and molecular mechanisms responsible for the development of synaptic and connectivity deficits in SHANK3-deficient human neurons.

Project 2: Mechanisms of epilepsy in human neurodevelopmental disorders: focus on 22q13 deletion syndrome. Epilepsy is a major source of morbidity and mortality associated with autism. However, the cellular and molecular mechanisms responsible for epilepsy in these individuals remain largely unknown. We have developed a new method for making human cortical organoids with functional neural networks from induced pluripotent stem cells (iPSC) and generated iPSCs from 22q13 deletion syndrome patients with drug-resistant epilepsy. The main goal of this project is to investigate the cellular and molecular mechanisms of drugresistant epilepsy using cortical organoids derived from iPSCs obtained from 22q13 deletion syndrome patients with drug-resistant epilepsy.

The University of Utah is one of the largest Research University in the American Midwest. It is located in Salt Lake City in the foothills of the Wasatch Mountains with several famous Ski Resorts and National Parks nearby. The university offers vibrant research environment with multiple state-of-art core research facilities and numerous interdisciplinary centers and initiatives, including NIH Center for Clinical and Translational Research, NIH Anticonvulsant Drug Development Program, Utah Neuroscience Initiative, and Utah Genome Project Initiative, to support innovative biomedical research.
The Department of Neurobiology and Anatomy is a highly collegial and collaborative department heavily invested in the “cutting-edge” neuroscience research. It provides exceptional mentoring support for postdocs interested in both academia and industry.

If you are interested in this opportunity, please email your CV and cover letter briefly describing your research interests to Dr. Alex Shcheglovitov (alexsh@neuro.utah.edu).

2019-02-01 2019-05-01

Team Leader: Nicholas Parrish M.D., Ph.D.

Research Field:
The primary objective of this research team is to investigate the potential immunological functions of endogenous viral sequences found in mammalian genomes. Some of these sequences have been observed to produce small RNAs that are antisense relative to the viral transcript from which they were derived (Parrish et al., RNA 2015). We are testing the hypothesis that such small RNAs are involved in antiviral immunity via RNA interference. This is interdisciplinary research integrating virology, immunology, genomics, epigenetics, RNA biology, evolutionary biology, and developmental biology. In the broad sense, we are studying cellular and organismal genomic plasticity in response to environmental stimuli (Sudmant, Parrish et al., Nature. 2015; Parrish et al., Current Opinion in Microbiology. 2016), in particular exogenous nucleic acid information (Parrish et al., Cell. 2018), and are open to hosting postdoctoral fellows with diverse research interests compatible with these topics.

Description:
The primary project investigates the role of endogenous viral sequences in viral infection. The researcher will assist with generation, maintenance, infection, and postinfection assessment of genetically modified mice. The successful applicant will take advantage of the existing strengths of the Center for Integrative Medical Sciences’immunology (Divisions of Human Immunology, Cancer Immunology, and Disease Systems Biology) and genomics (Division of Genomic Medicine) programs via active collaboration.

For more information, please email nicholas.parrish@riken.jp
or visit
http://www.ims.riken.jp/labo/76/index.html

2019-01-07 2019-04-07

The Srinivasan Lab at Oklahoma Medical Research Foundation (OMRF) studies lymphedema, a debilitating disease for which there is no cure. The lab uses state of the art technologies to dissect the roles of transcription factors and signaling molecules. We collaborate with numerous internationally recognized investigators thus offering career development opportunities for trainees. Please check our latest publications: Geng et al (2016) Dev Biol. (cover image) Jan 1;409(1):218-33, Cha et al (2016) Genes Dev. (cover image) June 16; 30: 1-16, and Cha et al (2018) Cell Reports (cover image) October 16; 25(3):571-584.
More information about our lab can be found at
https://omrf.org/researchfaculty/scientists/srinivasan-sathish/
We are recruiting highly motivated researchers who are interested in Cell biology and Biochemistry.

Required Qualifications
Ph.D., M.D., or Ph.D./M.D.,
Fresh graduates will be considered for postdoctoral fellowships, and more experienced researchers will be considered for the position of Staff Scientist. Salary of postdoctoral fellows is according to the stipulation of NIH. Salary of the Staff Scientist will be commensurate with experience. Only candidates with at least one first author publication in respected journals of Cell Biology or Biochemistry would be considered for the positions.
Please send CV, list of 3 references, reprints of publications and a brief summary of interests and career goals to Sathish-srinivasan@omrf.org.
OMRF is an independent, not-for-profit, biomedical research institute in Oklahoma City, USA. OMRF has been selected as one of the best research institutions for post-docs from 2011 to 2013 in the USA by The Scientist journal. Oklahoma City metropolitan area offers affordable housing, low cost of living, great public schools and numerous recreational activities. Additional information about OMRF can be found at https://omrf.org/.

2018-12-14 2019-06-14