Vol. 30, No. 5 (September 2025)

カブトムシの角はどのように形作られるのか?
In the larval head of the Japanese rhinoceros beetle (Trypoxylus dichotomus), the horn primordium is stored as a sac-like structure with wrinkles inscribed in a specific pattern. When the larva molts into a pupa, hemolymph is pumped into this sac, causing the wrinkles to stretch and the sac to expand, which results in the formation of the horn. Multiple research groups in Japan have investigated the three-dimensional morphogenesis of this horn. For further information, see the following publications: Matsuda et al. (2024) Development 151: dev202082, DOI: 10.1242/dev.202082; Matsuda et al. (2021) Sci. Rep. 11: 1017, DOI: 10.1038/s41598-020-79757-2; Adachi et al. (2020) Sci. Rep. 10: 18687, DOI: 10.1038/s41598-020-75709-y; Ohde et al. (2018) PLoS Genet. 14: e1007651, DOI: 10.1371/journal.pgen.1007651. As if celebrating the emergence of the beetles, the veins of the nearby leaves trace patterns reminiscent of the wrinkles in the horn primordium.

Genes to Cells © 2025 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 30, Issue 5, 2025.

Original Article 30:e70045
核タンパク質をコードするDyro遺伝子変異体では哺育細胞の核に異常があり、卵形成をmid-oogenesis checkpointで中断する
Loss of Nuclear Protein Dyro Causes Abnormalities in Nurse Cell Nuclei and Abort Oogenesis at Mid-Oogenesis Checkpoint

島 孝元、川端 有喜、八木 克将
https://onlinelibrary.wiley.com/doi/10.1111/gtc.70045
Original Article 30:e70046
胚盤胞補完法を用いて異種間キメラ体内で作製したラット肺上皮細胞の成熟状態
Maturation Status of Rat Lung Epithelial Cells in Interspecies Chimeras Generated by Blastocyst Complementation

村田 大和、由利 俊祐、伊川 正人、磯谷 綾子
https://onlinelibrary.wiley.com/doi/10.1111/gtc.70046
Original Article 30:e70044
ERSAtool - ユーザーフレンドリーなR/ShinyによるRNA-seq解析教育支援アプリケーション
ERSAtool: A User-Friendly R/Shiny Comprehensive Transcriptomic Analysis Interface Suitable for Education

Sujith Taridalu、Ayyappa Kumar Sista Kameshwar、鈴木 雅子
https://onlinelibrary.wiley.com/doi/10.1111/gtc.70044
Original Article 30:e70043
OPTN ロイシンジッパードメインとRAB8Aとの複合体形成における機能的・構造的知見
Functional and Structural Insights Into Complex Formation Between OPTN Leucine Zipper Domain and RAB8A

尾勝 圭、菊池 麗香、松田 憲之、深井 周也、山野 晃史
https://onlinelibrary.wiley.com/doi/10.1111/gtc.70043
Original Article 30:e70041
SIRPαスプライシングアイソフォーム間の機能的差異
Functional Differences Between SIRPα Splice Isoforms

梶田 美穂子、松井 耀史朗、杉本 康太朗、竹内 柊音、松本 翔太、奥村 隆弘、梶浦 裕之、元村 一基、竹田 篤史、越山 友美、白壁 恭子
https://onlinelibrary.wiley.com/doi/10.1111/gtc.70041
Meeting Report 30:e70039
第5回SMC複合体国際会議の報告
The meeting report on the 5th international conference of the chromosomal SMC complexes

仁木 宏典、村山 泰斗
https://onlinelibrary.wiley.com/doi/10.1111/gtc.70039
Original Article 30:e70040
ショウジョウバエはPaf1C複合体構成因子Ctr9の雄性生殖細胞特異的パラログを用いて性染色体を制御する
Paralog-Dependent Specialization of Paf1C Subunit, Ctr9, for Sex Chromosome Gene Regulation and Male Germline Differentiation in Drosophila

甲斐 歳惠、鄭 静瀾、井木 太一郎
https://onlinelibrary.wiley.com/doi/10.1111/gtc.70040
Original Article 30:e70042
TOBタンパク質によるCCR4–NOT複合体依存的かつ脱アデニル化非依存的な翻訳抑制
TOB Proteins Repress Translation via the CCR4–NOT Deadenylase Complex Independent of Deadenylation

宮崎 叶愛、友廣 拓生、船上 仁範、深尾 亜喜良、鈴木 亨、山本 雅、藤原 俊伸
https://onlinelibrary.wiley.com/doi/10.1111/gtc.70042