Vol. 29, No. 7(July 2024)

In establishing the left-right axis of the body in Drosophila, a torsion-like deformation of the cell occurs (cell chirality). Two myosin Is, Myo1D and Myo1C, are thought to be involved in this process, producing right-handed and left-handed cell chirality, respectively. A paper published in the May issue of this journal (Utsunomiya et al. (2024) Genes Cells 29: 380-396, DOI: 10.1111/gtc.13110) reported that when these myosin Is were expressed in macrophages to observe their interactions with the membrane at the single-molecule level, Myo1D exhibited mobility consistent with free diffusion, whereas Myo1C showed notably lower mobility. This picture, depicting two vortices in a strait, aptly illustrates their differences. Compared to the fast currents that produce the right-handed vortex in the back, the currents of the left-handed vortex in the foreground are docile.

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Genes to Cells © 2024 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 29, Issue 7, 2024.

Meeting Report

Pages: 525-531
第36回　国際哺乳類ゲノム会議：桜の下の科学者の集い
The 36th International Mammalian Genome Conference: A scientific gathering under the cherry blossoms in Tsukuba
阿部　訓也、桝屋　啓志、城石　俊彦
https://onlinelibrary.wiley.com/doi/10.1111/gtc.13131

Original Articles

Pages: 532-548
HPV18産生RNAをコアとした液滴形成によるがん原遺伝子の転写活性化機構
Chimera RNA transcribed from integrated HPV18 genome with adjacent host genomic region promotes oncogenic gene expression through condensate formation
古郡　華月、鈴木　秀文、阿部　竜太、堀内　恵子、秋山　智彦、廣瀬　智威、豊田　敦、高橋 秀尚
https://onlinelibrary.wiley.com/doi/10.1111/gtc.13121

Pages: 549-566
DNMT1のde novoメチル化活性によるマウス胚盤葉分化と生殖細胞分化の誘導メカニズム
DNMT1 can induce primary germ layer differentiation through de novo DNA methylation
伊藤　仁将、一丸－首浦　武作志、三浦　史仁、田嶋　正二、M. Azim Surani、伊藤　隆司、山口　新平、多田　政子
https://onlinelibrary.wiley.com/doi/10.1111/gtc.13130

Pages: 567-583
The HMG-box module in FACT is critical for suppressing epigenetic variegation of heterochromatin in fission yeast
Shinya Takahata, Asahi Taguchi, Ayaka Takenaka, Miyuki Mori, Yuji Chikashige, Chihiro Tsutsumi, Yasushi Hiraoka and Yota Murakami
https://onlinelibrary.wiley.com/doi/10.1111/gtc.13132

Brief Reports

Pages: 584-588
接合伝達プラスミドpLS20を枯草菌ゲノムに組み込むことで、ゲノムの一部（850kbp）を環状化し、他の枯草菌に丸ごと移動させた
Integrated conjugal plasmid pLS20 in the Bacillus subtilis genome produced 850-kbp circular subgenomes transmissible to another B. subtilis
板谷　光泰、片岡　正和
https://onlinelibrary.wiley.com/doi/10.1111/gtc.13120

Pages: 589-598
ヒトDSCR1の分裂酵母ホモログRcn1はカルシニューリンを介さずに亜ヒ酸耐性を制御する
Rcn1, the fission yeast homolog of human DSCR1, regulates arsenite tolerance independently from calcineurin
高崎　輝恒、馬場　明日香、久木田　優香、西田　藍子、上林　大起、萩原　加奈子、佐藤　亮介、石原　慶一、杉浦　麗子
https://onlinelibrary.wiley.com/doi/10.1111/gtc.13122

Pages: 599-607
Revisiting the gene mutations and protein profile of WT 9-12: An autosomal dominant polycystic kidney disease cell line
Hwa Chia Chai, Rhubaniya Mahendran, Kien Chai Ong and Kek Heng Chua
https://onlinelibrary.wiley.com/doi/10.1111/gtc.13129