Vol. 29, No. 3(March 2024)

mRNAワクチンの成功を記念する印籠
This is an ornamental tool called an 'inro' used to carry medicines in the Edo period. On the surface of this inro, the structure of N1-methyl-pseudouridine (N1mΨ), the key to the development of the mRNA vaccine against COVID-19, is schematically depicted with plum buds (oxygen atoms) and branches, using the maki-e lacquer decoration technique. Coronavirus particles are depicted on the toggle ('netsuke') used to secure the inro to the obi of the kimono. Perhaps one day, wherever we travel, we will enjoy our journey without fear of unknown viruses by swallowing a pill taken from our portable pill case like this inro.

Genes to Cells © 2024 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 29, Issue 3, 2024.

Review Article

Pages: 183-191 抗炎症作用におけるメトホルミンの標的分子 The anti-inflammatory effect of metformin; the molecular targets 坂田 菜摘 https://onlinelibrary.wiley.com/doi/10.1111/gtc.13098

Original Articles

Pages: 192-206 BRAF V600E変異を持つてんかん原性神経上皮性腫瘍のトランスクリプトーム解析 Transcriptional features of low-grade neuroepithelial tumors with the BRAF V600E mutation associated with epileptogenicity 飯島 圭哉、小松 泰子、宮下 聡、陶山 京香、村山 久美子、橋詰 晃一、田部 直央、宮田 元、岩崎 真樹、田谷 真一郎、星野 幹雄 https://onlinelibrary.wiley.com/doi/10.1111/gtc.13096 Pages: 207-216 細胞外αシヌクレインはHeLa細胞においてスフィンゴシン1リン酸受容体3型 (S1PR3)を介したカテプシンDのリソソームへの輸送を阻害する Extracellular α-synuclein impairs sphingosine 1-phosphate receptor type 3 (S1PR3)-regulated lysosomal delivery of cathepsin D in HeLa cells 西田 晋、Shubi Ambwene Matovelo、梶本 武利、中村 俊一、岡田 太郎 https://onlinelibrary.wiley.com/doi/10.1111/gtc.13093 Pages: 217-230 出芽酵母サブテロメア領域におけるGTPに依存したヘテロクロマチンの揺らぎによる発現制御 GTP-dependent regulation of heterochromatin fluctuations at subtelomeric regions in Saccharomyces cerevisiae 綾野 貴仁、横澤 拓馬、沖 昌也 https://onlinelibrary.wiley.com/doi/10.1111/gtc.13094 Pages: 231-253 FGF-1とFGF-2の最適なプライミング効果によるヒト脂肪由来間葉系幹細胞の脂肪前駆細胞系への運命決定促進 The optimized priming effect of FGF-1 and FGF-2 enhances preadipocyte lineage commitment in human adipose-derived mesenchymal stem cells Tanakorn Tarapongpun、Nattawat Onlamoon、椨 康一、Suebwong Chuthapisith、田賀 哲也 https://onlinelibrary.wiley.com/doi/10.1111/gtc.13095 Pages: 254-269 マウスTRPM2 isoform 7は、全長体マウスTRPM2をERADへターゲティングし発現を低下させることでその活性を抑制する Mouse transient receptor potential melastatin 2 (TRPM2) isoform 7 attenuates full-length mouse TRPM2 activity through reductions in its expression by targeting it to ER-associated degradation 山本 伸一郎、喜屋武 直人、金子 晃大、島村 昌直、吉田 卓史、清水 俊一 https://onlinelibrary.wiley.com/doi/10.1111/gtc.13097