Vol. 27, No. 6(June 2022)

Barbour et al. created an experimental food web, as depicted in this drawing, consisting of four species, Arabidopsis thaliana, two species of aphids, and a parasitoid wasp parasitizing the aphids, and examined the effects of alleles of three genes in the aliphatic glucosinolate biosynthesis pathway in A. thaliana on the survival of the four species (Barbour et al. (2022) Science 376: 70-73, DOI: 10.1126/science.abf2232). Their finding was that the null allele of one gene (AOP2) significantly reduced the extinction rate of the four. They call AOP2 a 'keystone gene,' in analogy to a keystone species. We would like to thank Dr. Toshiyuki Harumoto (Hakubi Center for Advanced Research, Kyoto University) for his advice on the drawing.

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Genes to Cells © 2022 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 27, Issue 6, 2022.

Review Article

Pages: 381-391 概日リズムと睡眠を制御するユビキチンプロテアソームシステム：ショウジョウバエ研究から分かったことを中心に Ubiquitin proteasome system in circadian rhythm and sleep homeostasis: Lessons from Drosophila 浮田　有美子、奥村　美紗子、千原　崇裕 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12935

Original Articles

Pages: 392-408 ウニ胚はオメプラゾールによりFアクチン分布のApical-Basal極性形成が阻害され部分外腸を形成する Partial exogastrulation due to apical–basal polarity of F-actin distribution disruption in sea urchin embryo by omeprazole 渡辺　開智、安井　優平、黒瀬　友太、藤井　雅史、山本　卓、坂本　尚昭、粟津　暁紀 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12934

Pages: 409-420 PAF1複合体は線虫C. elegansの卵形成を細胞自律的に促進する The PAF1 complex cell autonomously promotes oogenesis in Caenorhabditis elegans 久保田　幸彦、大田　菜摘、高塚　悠、海野　琢真、大浪　修一、杉本　亜砂子、伊藤　將弘 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12938

Pages: 421-435 KIF5AのALS関連遺伝子変異はKIF5Aのオリゴマー化と凝集を促進し神経毒性を引き起こす An ALS-associated KIF5A mutant forms oligomers and aggregates and induces neuronal toxicity 中野　朱莉、千葉　杏子、丹羽　伸介 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12936

Pages: 436-450 ラパログ依存的な接着頻度の亢進はアフリカツメガエル胚の中胚葉遊走を阻害する Rapalog-induced cell adhesion molecule inhibits mesoderm migration in Xenopus embryos by increasing frequency of adhesion to the ectoderm 宇佐美　知沙、猪股　秀彦 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12937

Pages: 451-464 ネクチン-4とp95-ErbB2によるT47D細胞の多層増殖促進機能 Stimulatory role of nectin-4 and p95-ErbB2 in multilayered T47D cell proliferation 慶田城　迅、亀山　武志、水谷　清人、高井　義美 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12940