Vol. 27, No. 2(February 2022)

When translation by the ribosome is stalled, the subsequent ribosome collides with the stalled ribosome, resulting in the accumulation of abnormal proteins. To prevent this occurring, the cell recognizes the specific structures caused by the ribosome collisions, and marks the stalled ribosome for removal. In budding yeast, collisions are detected by the E3 ubiquitin ligase Hel2, and the uS10 of the 40S subunit of the stalled ribosome is marked with a K63-branched ubiquitin chain. The two ribosome-like Yukidarumas (snowmen) in this picture also collide, and the male watcher is marking the one to be removed with tags that mimic a ubiquitin chain. For drawing this image, we referred to a website http://www.inada-lab.ims.u-tokyo.ac.jp/research/.

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Genes to Cells © 2022 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 27, Issue 2, 2022.

Original Articles

Pages: 77-92 枯草菌においてグルコ脂質とリポテイコ酸は副次的シグマ因子SigIと必須二成分制御系WalKRの活性に影響を与える Glucolipids and lipoteichoic acids affect the activity of SigI, an alternative sigma factor, and WalKR, an essential two-component system, in Bacillus subtilis 松岡　聡、清水　葉子、野辺　加織、松本　幸次、朝井　計、原　弘志 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12912

Pages: 93-112 ヘテロクロマチン領域の保持におけるヒストンバリアントH2A.Zの複数の機能 Histone variant H2A.Z plays multiple roles in the maintenance of heterochromatin integrity 月井　一輝、高畑　信也、村上　洋太 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12911

Pages: 113-123 ショウジョウバエの全身性自然免疫応答は、嗅覚受容体ニューロンの細胞死を引き起こす Systemic innate immune response induces death of olfactory receptor neurons in Drosophila 竹内　健一、本田　大智、奥村　美紗子、三浦　正幸、千原　崇裕 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12914

Pages: 124-137 海に生息する黒色酵母は細胞密度に応じて成長・分裂様式を変換する Growth and division mode plasticity is dependent on cell density in marine-derived black yeasts 五島　剛太 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12916

Brief Reports

Pages: 138-144 鶏卵成分の骨格筋損傷回復及び筋萎縮抑制効果 Egg components reverse the atrophy induced by injury in skeletal muscles 澤野　祥子、小林　佑哉、前澤　涼香、水野谷　航 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12915

Pages: 145-151 ショウジョウバエの脂肪体におけるヒトHIF-1αのホモログSimaはTribbles遺伝子の発現誘導を介して幼虫の成長を抑制する Sima, a Drosophila homolog of HIF-1α, in fat body tissue inhibits larval body growth by inducing Tribbles gene expression 野口　晃司、横関　京介、田中　裕子、鈴木　康浩、中島　一樹、西村　隆史、合田　亘人 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12913