Vol. 26, No. 6(June 2021)

Even in the same mammal, the time it takes for development is very different between humans and mice. The period of the segmentation clock in humans is about 5 hours, whereas that in mice is about 2 hours. The key regulator of the segmentation clock is the transcription factor HES7, whose expression level periodically increases or decreases by self-repression. Experiments in which human and mouse HES7 loci were swapped showed that differences in the speeds of intracellular biochemical reactions, such as gene expression and protein degradation, between species, rather than the sequences of HES7 loci themselves, produce the period difference. This finding suggests that the period difference of the segmentation clock may also be related to the difference in time scales in development between elephants and mice. We thank Dr. Miki Ebisuya (EMBL Barcelona) for her advice.

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Genes to Cells © 2021 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 26, Issue 6, 2021.

Review Article

Pages: 349-359 クロマチンリモデリングが複製非共役型維持DNAメチル化と染色体安定性に果たす役割：ICF症候群研究がもたらした知見 Chromatin remodeling in replication-uncoupled maintenance DNA methylation and chromosome stability: Insights from ICF syndrome studies 鵜木　元香 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12850

Original Articles

Pages: 360-380 マウスDNAポリメラーゼαのN末端の天然変性領域はテロメアにおいてPOT1a/bと相互作用する The intrinsically disordered N-terminal region of mouse DNA polymerase alpha mediates its interaction with POT1a/b at telomeres 水野　武、平林　佳、宮澤　沙絵、小林　百合香、荘司　健太、小林　正和、花岡　文雄、今本　尚子、鳥越　秀峰 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12845

Pages: 381-398 Pbp1はccr4Δおよびpop2Δ変異株の増殖不全に関わる遺伝子発現の異常を引き起こす Pbp1 mediates the aberrant expression of genes involved in growth defect of ccr4Δ and pop2Δ mutants in yeast Saccharomyces cerevisiae Arvin Lapiz Valderrama、藤井　志織、Duong Long Duy、入江　かおる、水野　智亮、須田　恭之、入江　賢児 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12846

Pages: 399-410 Sonic hedgehogは大脳新皮質領域の神経幹細胞数を増大させ、大脳新皮質表面積の拡大と皺形成をもたらす Sonic hedgehog expands neural stem cells in the neocortical region leading to an expanded and wrinkled neocortical surface Mohammed Shqirat、木下　晃、影山　龍一郎、大塚　俊之 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12847

Pages: 411-425 EGL-4/PKGは線虫の化学走性回路における介在神経の役割を感覚信号の統合を介して制御する EGL-4/PKG regulates the role of an interneuron in a chemotaxis circuit of C. elegans through mediating integration of sensory signals 日野　喬央、平井　祥太、石原　健、藤原　学 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12849

Pages: 426-446 14-3-3γ prevents centrosome duplication by inhibiting NPM1 function Arunabha Bose, Kruti Modi, Suchismita Dey, Somavally Dalvi, Prafful Nadkarni, Mukund Sudarshan, Tapas K. Kundu, Prasanna Venkatraman and Sorab N. Dalal https://onlinelibrary.wiley.com/doi/10.1111/gtc.12848

Pages: 447-454 UHRF2は紫外線によるATRの活性化に寄与する UV-induced activation of ATR is mediated by UHRF2 花木　駿介、羽原　誠、島田　緑 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12851