Vol. 26, No. 2(February 2021)

As with brown adipocytes, beige adipocytes are rich in mitochondria expressing Uncoupling Protein 1 (UCP1) and produce heat. However, their origin is white adipocytes, and their differentiation is induced by exposure to cold environments or stimulation with certain antidiabetic drugs. Now, in the cold snow scene where the induction of beige adipocytes is likely to progress, the snowball made by the children seems to have been changing into a beige adipocyte-like ball perhaps due to some stimulus.

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Genes to Cells © 2021 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 26, Issue 2, 2021.

Original Articles

Pages: 45-55 転写調節因子Rest遺伝子の欠損は、迷走神経への電気刺激により誘導される生理学的応答に変化を生じる Induced genetic ablation of Rest leads to the alteration of stimulus-induced response of the vagal nerve 青木　仁美、安部　力、原　明、宮崎　龍彦、森田　啓之、國貞　隆弘 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12819

Pages: 56-64 Gre 因子は転写複合体への温度・圧力変動ストレスを緩和し、転写の恒常性維持に寄与する Gre factors prevent thermal and mechanical stresses induced by terahertz irradiation during transcription 今清水　正彦、田中　真人、保科　宏道 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12822

Pages: 65-82 グアニン四重鎖形成核酸はSF3B2と相互作用し自然免疫遺伝子の発現を抑制する G-quadruplex-forming nucleic acids interact with splicing factor 3B subunit 2 and suppress innate immune gene expression 松本　恭子、岡本　啓治、岡部　幸子、藤井　理沙、植田　幸嗣、大橋　健一、清宮　啓之 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12824

Pages: 83-93 シアノバクテリアの時計タンパク質KaiCはATPをリズミックに放出する―ホタルルシフェラーゼ発光系を用いたATP放出のリアルタイム計測 Rhythmic adenosine triphosphate release from the cyanobacterial circadian clock protein KaiC revealed by real‐time monitoring of bioluminescence using firefly luciferase 武藤　梨沙、岩田　慶太、飯田　高広、石浦　正寛、小内　清 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12825

Pages: 94-108 UV-induced DNA damage disrupts the coordination between replication initiation, elongation, and completion Brian M. Wendel, Suzanne Hollingsworth, Charmain T. Courcelle and Justin Courcelle https://onlinelibrary.wiley.com/doi/10.1111/gtc.12826

Brief Report

Pages: 109-116 新規抗がん剤シーズACA-28によるERK MAPKホスファターゼDUSP6の抑制はHER2/ErB2過剰発現細胞の細胞死を誘導する Down-regulation of dual-specificity phosphatase 6, a negative regulator of oncogenic ERK signaling, by ACA-28 induces apoptosis in NIH/3T3 cells overexpressing HER2/ErbB2 神田　勇輝、水野　綾美、高崎　輝恒、佐藤　亮介、萩原　加奈子、益子　高、遠藤　雄一、田邉　元三、杉浦　麗子 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12823