Vol. 25, No. 7(July 2020)

Organoids are miniaturized organs cultured in vitro. There are great expectations for its potential, including understanding of the mechanism of organ development, construction of disease models, search for new drugs, and application to regenerative medicine. Now, balloons imitating organoids are flying over the city one after another to announce the advent of a new era. The row of the buildings on the lower right looks like intestinal absorptive cells and Paneth cells lined up. For drawing the balloons, we referred to the following papers: From left, cerebral neocortex (Seto and Eiraku (2019) Neurosci. Res. 138, 33-42), intestine (Lancaster and Knoblich (2014) Science 345, 1247125), and optic cup (Sasai et al. (2012) Development 139, 4111-4121).

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Genes to Cells © 2020 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 25, Issue 7, 2020.

Review Article

Pages: 443-449 ヒスチジン脱炭酸酵素誘導によるヒスタミン合成制御を介した免疫調節作用 Histamine and histidine decarboxylase: immunomodulatory functions and regulatory mechanisms 高井　淳、森口　尚 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12774

Original Articles

Pages: 450-465 TDP2は、前立腺上皮細胞における、アンドロゲン刺激で発生する染色体不安定性を抑制する TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands Md. Rasel Al Mahmud、石井　健一朗、Cristina Bernal-Lozano、Irene Delgado-Sainz、戸井　雅和、赤松　秀輔、福本　学、渡邉　昌俊、武田　俊一、Felipe Cortés-Ledesma、笹沼　博之 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12770

Pages: 466-474 Homeodomain protein DLX4 facilitates nasopharyngeal carcinoma progression via up-regulation of YB-1 Zeyi Ling, Xiaoli Long, Jie Li and Mingliang Feng https://onlinelibrary.wiley.com/doi/10.1111/gtc.12772

Pages: 475-482 高CO₂はシロイヌナズナ子葉のサテライト気孔の発生を促進する Elevated CO₂ promotes satellite stomata production in young cotyledons of Arabidopsis thaliana 檜垣　匠、秋田　佳恵、馳澤　盛一郎 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12773

Pages: 483-497 培養がん細胞ではオートファジー阻害によって可溶型プロレニン受容体の細胞内タンパク量が増大する Increased soluble (pro)renin receptor protein by autophagy inhibition in cultured cancer cells 遠藤　萌恵、大場　浩史、佐藤　重光、横田　柚梨菜、高橋　和広 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12776

Pages: 498-509 CRISPR-Cas9により導入された変異の解析（ジェノタイピング）のためのシンプルで実用的なワークフロー A simple and practical workflow for genotyping of CRISPR-Cas9-based knockout phenotypes using multiplexed amplicon sequencing 飯田　緑、鈴木　美有紀、坂根　祐人、西出　浩世、内山　郁夫、山本　卓、鈴木　賢一、藤井　聡 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12775

Brief Report

Pages: 510-517 RB1遺伝子を欠失したヒトiPS細胞株の性質の検討 Characterization of human-induced pluripotent stem cells carrying homozygous RB1 gene deletion Xiaoyue Deng、岩川　外史郎、福島　正哉、渡邉　すみ子 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12771