Vol. 24, No. 11(November 2019)

Several types of super-resolution fluorescence microscopies have been invented and begun to spread. One of them is the stimulated emission depletion (STED) microscopy, and its principle is illustrated in this drawing. In the traditional fluorescence microscopy, it is difficult to observe in sub-diffraction limit resolution, since there is a limit to reducing the spot size of excitation beam due to the diffraction limit. On the other hand, a STED microscope can narrow the excited area enough by overlapping the excitation beam and doughnut-shape STED beam. In this drawing, the woman's two umbrellas emit the excitation beam (cyan) and STED beam (orange) overlapping each other, and the fluorescence (green) is emitted from the area much narrower than the excitation beam spot.

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Genes to Cells © 2019 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 24, Issue 11, 2019.

Original Articles

Pages: 688-704 ワレモコウの根茎から精製されたエラグ酸は、PTENの活性制御を介し、悪性黒色腫細胞B16F10にG1期停止を誘導する Ellagic acid, extracted from Sanguisorba officinalis, induces G1 arrest by modulating PTEN activity in B16F10 melanoma cells 譚　亦珣、首藤　敏之、吉田　有希、杉山　悠真、司　家鶯、塚野　千尋、竹本　佳司、垣塚　彰 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12719

Pages: 705-718 ラメリポディア先端のアクチン反矢じり端は、力覚センサーとして機能する Lamellipodium tip actin barbed ends serve as a force sensor 小関　和馬、谷口　大相、山城　佐和子、水野　裕昭、Dimitrios Vavylonis、渡邊　直樹 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12720

Pages: 719-730 アミロイド前駆体タンパク質(APP)は神経細胞においてアンドロゲンにより誘導され、RNA結合タンパク質PSF/SFPQの標的遺伝子として制御されている Amyloid precursor protein, an androgen-regulated gene, is targeted by RNA-binding protein PSF/SFPQ in neuronal cells 高山　賢一、藤原　恭子、井上　聡 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12721

Pages: 731-745 IFT-Bタンパク質は、繊毛形成に伴い細胞内の未知のコンパートメントに局在するようになる Ciliogenesis-coupled accumulation of IFT-B proteins in a novel cytoplasmic compartment Lynda Lamri、Wang Kyaw Twan、加藤　孝信、Yanick Botilde、高岡　勝吉、井川　弥生、西村　博美、福本　明美、峰岸　かつら、水野　克俊、濱田　博司 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12722

Pages: 746-755 ZBTB24タンパク質のヘテロクロマチンへの局在及び転写活性化能を担うドメイン・モチーフ解析 Identification of ZBTB24 protein domains and motifs for heterochromatin localization and transcriptional activation Sharmin Aktar、佐々木　裕之、鵜木　元香 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12723