Vol. 24, No. 4(April 2019)

The single-cell RNA-sequencing technology has a possibility of changing biological studies completely. This is a schematic image of the technology. As with petals of the cherry blossoms, for example, even a number of early embryonic cells indistinguishable from each other can be clustered and visualized based on gene expression data, just as the image is projected on the water surface, and then further analysis can be progressed. Data: Dr. Takefumi Kondo and Mr. Shunta Sakaguchi (Kyoto University).

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Genes to Cells © 2019 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 24, Issue 4, 2019.

Original Articles

Pages: 272-283 ヒトTHO複合体はHSP70遺伝子の転写終結とmRNA解離を連繋させる Human THO coordinates transcription termination and subsequent transcript release from the HSP70 locus 片平　じゅん、石川　浩基、辻村　翔、黒野　定、檜枝　美紀 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12672

Pages: 284-296 スピロノラクトンで誘導されるXPBの分解はCDK7キナーゼとSCF^FBXL18 E3リガーゼに依存する Spironolactone-induced XPB degradation depends on CDK7 kinase and SCF^FBXL18 E3 ligase 上田　将信、松浦　顕教、河合　秀彦、若杉　光生、松永　司 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12674

Pages: 297-306 自動FRET定量法によって明らかにされたERKシグナルの核-細胞質間の差次的活性化 Automated FRET quantification shows distinct subcellular ERK activation kinetics in response to graded EGFR signaling in Drosophila 小椋　陽介、Mustafa M. Sami、和田　宝成、林　茂生 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12679

Pages: 307-317 Genetic interactions between Ror2 and Wnt9a, Ror1 and Wnt9a and Ror2 and Ror1: Phenotypic analysis of the limb skeleton and palate in compound mutants Martina Weissenböck、Richard Latham、西田　満、Lena Ingeborg Wolff、Hsin-Yi Henry Ho、南　康博、Christine Hartmann https://onlinelibrary.wiley.com/doi/10.1111/gtc.12676

Brief Reports

Pages: 318-323 Evolutionary origin of the type 2 corticotropin-releasing hormone receptor γ splice variant Bert De Groef, Stanisław K. Wawrzyczek, Yugo Watanabe, Ellyse B. Noy, David H. Reser and Sylvia V. H. Grommen https://onlinelibrary.wiley.com/doi/10.1111/gtc.12673

Pages: 324-331 Transcriptome analysis reveals ambiguous phenotypes of murine primitive endoderm-related stem cell lines Yixiang Zhong and Bert Binas https://onlinelibrary.wiley.com/doi/10.1111/gtc.12678