Vol. 24, No. 1(January 2019)

Kagami-mochi (mirror rice cake) is a representative of Japanese New Year decorations. It usually consists of a couple of stacked large round-shaped mochi that resemble ancient bronze mirrors with one daidai (Japanese bitter orange) on top. This year, however, our kagami-mochi is somewhat different from the usual; it is a so-called ribosome-like kagami-mochi. Two stacked mochi likened the ribosome's large and small subunits bind to a gohei (a folded ribbon of paper) that resembles an mRNA encoding (DAIDAI)_n amino acid sequence, and a chain of daidais extends upward from the mochi likened the large subunit. It looks like a polypeptide chain itself.

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Genes to Cells © 2019 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 24, Issue 1, 2019.

Review Article

Pages: 6-30 哺乳類における減数分裂特異的コヒーシン複合体 The cohesin complex in mammalian meiosis 石黒　啓一郎 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12652

Original Articles

Pages: 31-40 CRMP2の遺伝的なリン酸化抑制によるMPTPパーキンソン病モデルマウスの病態に対する治療効果 Genetic suppression of collapsin response mediator protein 2 phosphorylation improves outcome in methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's model mice 富樫　健太郎、長谷川　正弥、長井　淳、登内　愛音、増川　大輝、Kenneth Hensley、五嶋　良郎、大島　登志男 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12651

Pages: 41-59 発生期における中脳背側の細胞種に基づく包括的解析 Comprehensive and cell type-based characterization of the dorsal midbrain during development 有村　奈利子、出羽　健一、岡田　茉子、柳川　右千夫、田谷　真一郎、星野　幹雄 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12656

Pages: 60-69 ピルビン酸とピルビン酸エチルはPI3K/AKT、GSK3βおよびROS-ERKシグナル伝達経路を介してB16F10メラノーマ細胞のメラニン産生を阻害する Pyruvic acid/ethyl pyruvate inhibits melanogenesis in B16F10 melanoma cells through PI3K/AKT, GSK3β, and ROS-ERK signaling pathways 周　思奇、坂本　和一 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12654

Pages: 70-81 線虫におけるベンジルイソキノリンアルカロイドの世代を越えた脂質蓄積抑制 Transgenerational lipid-reducing activity of benzylisoquinoline alkaloids in Caenorhabditis elegans Yit-lai Chow、佐藤　文彦 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12657

Pages: 82-93 リン酸化プロテオームデータを用いたシグナル伝達から細胞機能へのグローバル制御ネットワークの再構築 Reconstruction of global regulatory network from signaling to cellular functions using phosphoproteomic data 川田　健太郎、柚木　克之、幡野　敦、小鍛治　俊也、富沢　瑶子、藤井　雅史、宇田　新介、久保田　浩行、松本　雅記、中山　敬一、黒田　真也 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12655

Brief Report

Pages: 94-106 減数分裂期特異的コヒーシン構成要素のRec8はSUNドメインタンパク質のMps3の核膜への局在を制御する Meiosis-specific cohesin component, Rec8, promotes the localization of Mps3 SUN domain protein on the nuclear envelope Jagadeeswara Rao Bommi、Hanumanthu Bala Durga Prasada Rao、Kiran Challa、東出　望花、新名主　カオリ、中山　潤一、篠原　美紀、篠原　彰 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12653