Vol. 22, No. 12(December 2017)

You can perform polymerase chain reaction (PCR) without using a thermal cycler if you follow this drawing. Time management and temperature control are critically important for getting good yields of reaction products with high reproducibility and specificity. But, of course, safety first. Ouch! The smoke got in her eyes!

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Genes to Cells © 2017 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 22, Issue 12, 2017.

Original Articles

Pages: 982-992 Nicotinamide phosphoribosyltransferaseは、SIRT1活性と抗酸化遺伝子発現を上昇させてマウス初代細胞の老化を遅らせる Nicotinamide phosphoribosyltransferase delays cellular senescence by upregulating SIRT1 activity and antioxidant gene expression in mouse cells Fiqri Dizar Khaidizar、中畑　泰和、久米　光、隅澤　杏介、河野　憲二、松井　貴輝、別所　康全 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12542

Pages: 993-1003 BCL-XLは腫瘍抑制分子RASSF6に拮抗してp53を抑制する BCL-XL binds and antagonizes RASSF6 tumor suppressor to suppress p53 expression 許　暁茵、岩佐　宏晃、シャカワット・ホセイン、アラドハン・サルカー、丸山　順一、松崎－有本　京子、畑　裕 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12541

Brief Report

Pages: 1004-1010 線虫C. elegansのp53/CEP-1障害は、エネルギー代謝の加齢に伴うアンバランスを介して寿命延長に関与する Impaired p53/CEP-1 is associated with lifespan extension through an age-related imbalance in the energy metabolism of C. elegans 簗瀬　澄乃、須田　斎、安田　佳代、石井　直明 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12540