Vol. 22, No. 2(February 2017)

Walking monozygotic twin sisters in the snow are sharing an umbrella. They share the same genotype; however, they seem to have a different personality and taste as their kimono. It has been pointed out that the difference in epigenome would cause such difference in personality. The data printed on their sleeves that was obtained with the bisulfite sequencing (a method that can detect methylation of individual cytosine residues in DNA) and is showing their methylation patterns at a certain locus of the genome suggests that there are epigenetic differences between them. Our knowledge of the relationship between presumed hereditary traits or diseases and epigenetics will increase through studies of monozygotic twin-pairs of which one twin has such traits or diseases.

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Genes to Cells © 2017 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 22, Issue 2, 2017.

Meeting Report

Pages: 130-134 地球全体の幸福に貢献する酵母：淡路島で開催された第14回酵母国際会議（ICY14）のレポート Yeasts for Global Happiness: report of the 14th International Congress on Yeasts (ICY14) held in Awaji Island 渡辺　大輔、高木　博史 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12471

Original Articles

Pages: 135-147 酵母トア複合体１のアミノ酸センシングにおけるtRNAの新規な機能 Novel tRNA function in amino acid sensing of yeast Tor complex1 鎌田　芳彰 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12462

Pages: 148-159 ザイールエボラウイルスの感染価を上昇させる糖蛋白質のアミノ酸変異の同定 Functional mutations in spike glycoprotein of Zaire ebolavirus associated with an increase in infection efficiency 上田（高橋）　真保子、黒崎　陽平、泉　泰輔、中野　雄介、オラミデ　オロニニ、安田　二朗、小柳　義夫、佐藤　佳、中川　草 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12463

Pages: 160-173 C型肝炎ウイルスの未成熟型コア蛋白質は酵母モデルシステムにおいて小胞体内腔の小胞体関連分解（ERAD-L)の阻害することで小胞体ストレス応答を誘導する Immature Core protein of hepatitis C virus induces an unfolded protein response through inhibition of ERAD-L in a yeast model system 高橋　庄太、佐藤　直子、菊池　純一、柿沼　秀明、大川　潤、増山　由希子、岩佐　真吾、色川　隼人、黄　基旭、永沼　章、小原　道法、久下　周佐 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12464

Pages: 174-188 胎盤における胎児毛細血管網の損傷が Peg11/Rtl1ノックアウトマウスの胎児期中期・後期致死と胎盤形成不全の原因である Severe damage to the placental fetal capillary network causes mid- to late fetal lethality and reduction of placental size in Peg11/Rtl1 KO mice 北澤　萌恵、田村　勝、金児－石野　知子、石野　史敏 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12465

Pages: 189-202 アクチビンAはERK1/2 MAPK経路阻害と組み合わせることによりマウスES細胞の自己複製能を維持する Activin A in combination with ERK1/2 MAPK pathway inhibition sustains propagation of mouse embryonic stem cells 蘆田　勇平、小山（中島）　明、廣田　聡、山本　拓也、西田　栄介 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12467

Pages: 203-209 半導体バイオセンサを用いた血管内皮細胞を浸潤するがん細胞のin situ電気的モニタリング In situ electrical monitoring of cancer cells invading vascular endothelial cells with semiconductor-based biosensor 坂田　利弥、松瀬　雄亮 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12473

Pages: 210-219 オクトパミンは飢餓応答性転写因子DAF-16を介して酸化ストレス耐性を上昇させる Octopamine enhances oxidative stress resistance through the fasting-responsive transcription factor DAF-16/FOXO in C. elegans 星川　悠、宇野　雅晴、本城　咲季子、西田　栄介 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12469

Pages: 220-236 タンパク質リン酸化酵素 PKN2 はマウスの胚発生とマウス線維芽細胞の増殖に必須である PKN2 is essential for mouse embryonic development and proliferation of mouse fibroblasts 團野　紗莉、窪内　康二、Mona Mehruba、阿部　学、夏目　里恵、﨑村　建司、江口　賢史、岡　昌宏、福本　毅、平島　正則、安田　浩樹、向井　秀幸 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12470

Brief Report

Pages: 237-244 セクレトーム解析による、神経分化の際に起こるメタロプロテアーゼ依存的なエクトドメインシェディングの解明 Secretome analysis to elucidate metalloprotease-dependent ectodomain shedding of glycoproteins during neuronal differentiation 津曲　和哉、白壁　恭子、小椋　麻由、佐藤　文規、石濱　泰、瀬原　淳子 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12466