Vol. 22, No. 1(January 2017)

In recent years, sirtuin family genes have attracted attention because it has been reported that their activation extended lifespan in some animal species and yeast. Sirtuin family consists of several classes, and the majority of them encode NAD⁺-dependent deacetylase. The arrow in this picture is called 'hamaya,' which is one of Japanese New Year's good luck charms. It is decorated with two 'ema's (wooden votive plaques) likened five-membered ring of ribose with drawings of a crane and a turtle, common symbols of longevity in Japan. The arrow as a whole is mimicking the structure of NAD⁺, which is required for sirtuin's deacetylase activity.

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Genes to Cells © 2017 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 22, Issue 1, 2017.

Review Article

Pages: 6-31 哺乳類Hippo経路の機能 Hippo vs. Crab: tissue-specific functions of the mammalian Hippo pathway 西尾　美希、前濱　朝彦、後藤　裕樹、中谷　圭佑、加藤　稚子、大森　裕文、宮地　洋佑、富樫　英、下野　洋平、鈴木　聡 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12461

Original Articles

Pages: 32-44 Structural and functional analysis of cyclophilin PpiB mutants supports an in vivo function not limited to prolyl isomerization activity Aggeliki Skagia, Eleni Vezyri, Markezina Sigala, Areti Kokkinou, Michael Karpusas, Anastasia Venieraki, Panagiotis Katinakis and Maria Dimou https://onlinelibrary.wiley.com/doi/10.1111/gtc.12452

Pages: 45-58 Irradiation with UV-C inhibits TNFα-dependent activation of the NF-κB pathway in a mechanism potentially mediated by reactive oxygen species Katarzyna Szoltysek, Anna Walaszczyk, Patryk Janus, Marek Kimmel and Piotr Widlak https://onlinelibrary.wiley.com/doi/10.1111/gtc.12455

Pages: 59-70 分裂酵母のTel2結合型ストレス応答複合体形成はCK2によるTel2のリン酸化に依存しない CK2 phospho-independent assembly of the Tel2-associated stress-signaling complexes in Schizosaccharomyces pombe 井上　春奈、杉本　静香、竹下　由美子、竹内　美穂、畠中　内子、長尾　恒治、林　武志、國分　綾、柳田　充弘、加納　純子 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12454

Pages: 71-83 グルコース輸送体遺伝子Slc2a1のβ-ヒドロキシ酪酸によるエピジェネティックな制御は、絶食時の脳への優先的なグルコース供給の基礎となる Epigenetic regulation of the glucose transporter gene Slc2a1 by β-hydroxybutyrate underlies preferential glucose supply to the brain of fasted mice 種子島　幸祐、佐藤　由紀子、船越　政史、西藤　泰昌、相垣　敏郎、原　孝彦 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12456

Pages: 84-93 パルスフィールド電気泳動によるDNA二重鎖切断の検出 Detection of DNA double-strand breaks by pulsed-field gel electrophoresis 川島　友莉、山口　奈保美、手島　理絵、楢原　久司、山岡　吉生、穴井　博文、西田　欣広、花田　克浩 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12457

Pages: 94-104 酵母における電位作動性カルシウムCa²⁺チャネルホモログと細胞膜H⁺-ATPaseのカップリング Coupling of a voltage-gated Ca²⁺ channel homologue with a plasma membrane H⁺-ATPase in yeast 長　敏彦、石井（加藤）　彩、深田　優子、中山　義敬、飯田　和子、深田　正紀、飯田　秀利 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12458

Brief Reports

Pages: 105-114 体性感覚神経細胞の樹状突起分岐数は栄養依存的に増加する Nutrient-dependent increased dendritic arborization of somatosensory neurons 渡辺　佳織、古溝　優生、碓井　理夫、服部　佑佳子、上村　匡 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12451

Pages: 115-123 アスパラガスの性決定に関わるMYB転写因子 MYB transcription factor gene involved in sex determination in Asparagus officinalis 村瀬　浩司、重信　秀治、藤井　壮太、上田　和季、村田　亨謙、阪本　愛、和田　七夕子、山口　勝司、刑部　祐里子、刑部　敬史、菅野　明、尾崎　行生、高山　誠司 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12453