Vol. 21, No. 11(November 2016)

It is known that an increase of cytosolic concentration of calcium ion (Ca²⁺) like a wave is initiated from the point of sperm entry and propagates throughout the egg after fertilization in many animal species. This calcium wave is caused by a kind of chain reaction; activated phospholipase C (PLC) produces inositol 1,4,5-triphosphate (IP₃) that induces release of Ca²⁺ from the endoplasmic reticulum (ER) near the egg surface, and released Ca²⁺ induces further release of Ca²⁺ from nearby ER. The leaves on the round-shape mountain are turning red like a wave coming down from the top of the mountain as if mimicking the calcium wave.

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Genes to Cells © 2016 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 21, Issue 11, 2016.

Original Articles

Pages: 1150-1163 3つのDNA切断酵素（DNase γ 、DNase I、CAD）は協調して死細胞を分解する DNase γ , DNase I and caspase-activated DNase cooperate to degrade dead cells 小山　諒、荒井　智也、木島　真理恵、佐藤　祥子、三浦　成敏、湯浅　真、北村　大介、水田　龍信 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12433

Pages: 1164-1175 血管内皮細胞特異的なERK活性は血管形成の新規マーカーとなる ERK activation in endothelial cells is a novel marker during neovasculogenesis 増田（長澤）　あゆみ、寺井　健太 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12438

Pages: 1176-1194 大脳皮質ニューロンの最終分化はRanGAP介在性核輸送システムを急速に改変する Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system 藤原　一志郎、長谷川　孝一、岡　正啓、米田　悦啓、吉川　和明 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12434

Pages: 1195-1208 シロイヌナズナではDNA損傷により活性化されるサイトカイニン合成が側根形成を抑制する DNA damage inhibits lateral root formation by up-regulating cytokinin biosynthesis genes in Arabidopsis thaliana La Ode Muhammad Muchdar Davis、荻田　伸夫、稲垣　宗一、高橋　直紀、梅田　正明 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12436

Pages: 1209-1222 小規模および１細胞ショットガンバイサルファイトシーケンスによる反復配列DNAメチローム解析 Repetitive DNA methylome analysis by small-scale and single-cell shotgun bisulfite sequencing 小林　久人、小池　佐、坂下　陽彦、田中　啓介、隈本　宗一郎、河野　友宏 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12440

Pages: 1223-1232 ユビキチンプロテアソーム系によるTLPの分解は基本転写因子TFIIAとの結合によって阻害される Ubiquitin-proteasome-dependent degradation of TBP-like protein is prevented by direct binding of TFIIA 磯貝　桃子、鈴木　秀文、前田　亮、田村　隆明 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12441

Pages: 1233-1243 リン酸化酵素TAK1は免疫グロブリンλ鎖陽性B細胞の生存を維持する TAK1 maintains the survival of immunoglobulin λ-chain-positive B cells 篠原　久明、長嶋　剛史、Marilia I. Cascalho、黒崎　知博 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12442

Brief Reports

Pages: 1244-1252 変異型H-Ras遺伝子を導入したマウス乳腺細胞を同種同所移植することによって確立した悪性葉状腫瘍マウスモデル Development of mouse models of malignant phyllodes tumors by transplantation of syngeneic mammary gland cells expressing mutant H-Ras 髙本　やよい、有馬　好美、佐谷　秀行 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12435

Pages: 1253-1262 B型肝炎ウイルス不活性化のためのCRISPR-Cas9ヌクレアーゼおよびCRISPR-Cas9ニッカーゼの多重ベクター Highly multiplexed CRISPR-Cas9-nuclease and Cas9-nickase vectors for inactivation of hepatitis B virus 佐久間　哲史、柾木　慶一、茶山　弘美、持田　圭次、山本　卓、茶山　一彰 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12437

Pages: 1263-1269 ヒトarc mRNAの樹状突起内輸送配列は、翻訳依存的なRNA分解活性を持つ Dendritic transport element of human arc mRNA confers RNA degradation activity in a translation-dependent manner 二宮　賢介、大野　睦人、片岡　直行 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12439