Vol. 21, No. 6(June 2016)

Among phenotypes, quantitative traits are usually caused by many chromosomal loci (quantitative trait locus, QOL) in a complex manner, and researches using dogs have been fruitful. A number of dog breeds have been produced by human beings. The morphological character is highly variable among breeds, but uniformed within the same breed. Genome-wide association studies that coupled craniometric data obtained from various dog breeds have been conducted, and QTLs in which SNPs that might affect the skull shape existed concentratively were identified. One of the QTLs was mapped near BMP3 gene on Ch. 32, and it was shown that most breeds with shortened head had a common missense mutation in BMP3. Data on the background: Figure 3 of Schoenebeck et al. (2012) PLoS Genet. 8, e1002849 (DOI: 10.1371/journal.pgen.1002849). Upper panel: SNP distribution around BMP3 locus among various dog breeds. Lower panel: Plots of important SNPs (conserved, exonic, etc.) extracted from the upper panel.

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Genes to Cells © 2016 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 21, Issue 6, 2016.

Original Articles

Pages: 530-542 酸化・金属ストレスに応答する多様かつ必須な分裂酵母遺伝子群；グルタチオン関連遺伝子および他の防御遺伝子破壊株の比較解析 Diverse fission yeast genes required for responding to oxidative and metal stress: Comparative analysis of glutathione-related and other defense gene deletions Tomáš Pluskal、佐二木　健一、Joanne Becker、武田　鋼二郎、柳田　充弘 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12359

Pages: 543-552 Identification of YPL014W (Cip1) as a novel negative regulator of cyclin-dependent kinase in Saccharomyces cerevisiae Ping Ren, Asrar Malik and Fanli Zeng https://onlinelibrary.wiley.com/doi/10.1111/gtc.12361

Pages: 553-567 マウス胎児線維芽細胞におけるBACH1-Pparg経路を介した脂肪細胞分化阻害 Genomewide approaches for BACH1 target genes in mouse embryonic fibroblasts showed BACH1-Pparg pathway in adipogenesis 松本　光代、近藤　敬一、白木　琢磨、アンドレイ　ブリドン、舟山　亮、中山　啓子、八重樫　伸生、片桐　秀樹、五十嵐　和彦 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12365

Pages: 568-578 ウニ胚における左右相称性の破れに繊毛が関与する Cilia play a role in breaking left–right symmetry of the sea urchin embryo 竹本　あゆみ、宮本　達雄、下野　文栄、黒木　奈緒、白江－倉林　麻貴、粟津　暁紀、鈴木　賢一、山本　卓、坂本　尚昭 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12362

Pages: 579-593 mTORC2はfilamin Aを介して接着斑形成と細胞運動を制御する Mammalian target of rapamycin (mTOR) complex 2 regulates filamin A-dependent focal adhesion dynamics and cell migration 佐藤　龍洋、石井　淳子、太田　悠貴、佐々木　恵理、柴垣　芳夫、服部　成介 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12366

Pages: 594-607 アニリン関連タンパク質 Mid1 は分裂酵母Schizosaccharomyces japonicusの収縮環形成のタイミングを制御する Anillin-related protein Mid1 regulates timely formation of the contractile ring in the fission yeast Schizosaccharomyces japonicus 安田　剛、高稲　正勝、沼田　治、中野　賢太郎 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12368

Pages: 608-623 E3リガーゼのユビキチン化特性評価のための蛍光タンパク質ミドリシアン/モノクサビラオレンジを用いたFRET法の確立 Midori-ishi Cyan/monomeric Kusabira-Orange-based fluorescence resonance energy transfer assay for characterization of various E3 ligases 大坪　亮太、キム　ミンス、李　智慧、笹川　千尋 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12369

Pages: 624-638 ケモカインリガンド11によって誘導される好酸球による腫瘍の血管新生阻害と壊死 CCL11-induced eosinophils inhibit the formation of blood vessels and cause tumor necrosis 邢　岩江(XING Yanjiang)、田　義軍(Yijun Tian)、黒澤　崇将、松井　さやか、藤間　真紀、箭内　敬典、呉　瓊(WU Qiong)、杉本　健吉 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12371

Pages: 639-647 RNA-seq発現データのパラメトリックな解析 Parametric analysis of RNA-seq expression data 小西　智一 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12372

Pages: 648-660 ΔNp63α controls YB-1 protein stability: evidence on YB-1 as a new player in keratinocyte differentiation Orsola di Martino, Annaelena Troiano, Andrea Maria Guarino, Alessandra Pollice, Maria Vivo, Girolama La Mantia and Viola Calabrò https://onlinelibrary.wiley.com/doi/10.1111/gtc.12373

Brief Reports

Pages: 661-669 Wntシグナル強度を反映するレポーターマウスR26-WntVis R26-WntVis reporter mice showing graded response to Wnt signal levels 竹本　龍也、阿部　高也、清成　寛、中尾　和貴、古田　泰秀、鈴木　仁美、高田　慎治、藤森　俊彦、近藤　寿人 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12364

Pages: 670-676 出生後のマウスにおけるdok-7遺伝子の発現抑制は神経筋シナプスの構造異常を伴う筋無力症様の病態を引き起こす Postnatal knockdown of dok-7 gene expression in mice causes structural defects in neuromuscular synapses and myasthenic pathology 江口　貴大、手塚　徹、三好　貞徳、山梨　裕司 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12370