Vol. 21, No. 3(March 2016)

Spring, that is the season of arousal for many living creatures. Even among mammals, some squirrels, bears and bats hibernate. This woman is researching hibernation of an individual of the Siberian chipmunk. The body temperature of hibernating chipmunk firstly drops to near ambient temperature, and reciprocally repeats the state of less than 10 °C (sustained hibernation) and the state of almost 37 °C (inter-bout arousal) like the chart on this drawing. We hope that life science will shed light on the mechanisms of various environmental adaptations of life. We thank Dr. Yoshifumi Yamaguchi (Graduate School of Pharmaceutical Sciences, The University of Tokyo) for his valuable suggestions for our drawing. Inspired by Figure 1 in Epperson & Martin (2002) Physiol. Genomics 10, 93-102.

---

Genes to Cells © 2016 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 21, Issue 3, 2016.

Original Articles

Pages: 218-225 ヒストン脱メチル化酵素GASC1/KDM4C/JMJD2C低発現変異マウスにおけるGFAP陽性アストロサイトの増加 Increase in GFAP-positive astrocytes in histone demethylase GASC1/KDM4C/JMJD2C hypomorphic mutant mice 須藤　元輝、鹿川　哲史、國分　康博、稲澤　譲治、田賀　哲也 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12331

Pages: 226-240 Calcium modulation of doxorubicin cytotoxicity in yeast and human cells Thi Thuy Trang Nguyen, Ying Jun Lim, Melanie Hui Min Fan, Rebecca A. Jackson, Kim Kiat Lim, Wee Han Ang, Kenneth Hon Kim Ban and Ee Sin Chen https://onlinelibrary.wiley.com/doi/10.1111/gtc.12346

Pages: 241-251 脳腫瘍幹細胞によるGM-CSFを介した腫瘍促進性CD11c^highマクロファージの誘導 Induction of protumoral CD11c^high macrophages by glioma cancer stem cells through GM-CSF 國分　康博、椨　康一、村松　希美、王　文茜、室田　吉貴、信久　幾夫、地主　将久、田賀　哲也 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12333

Pages: 252-263 ヒストンシャペロンヒトNAP1のC末酸性ドメインはヒストンH2A-H2Bと結合するがH3-H4とは結合しない C-terminal acidic domain of histone chaperone human NAP1 is an efficient binding assistant for histone H2A-H2B, but not H3-H4 大友　秀明、明石　知子、森脇　義仁、奥脇　暢、越阪部　晃永、永田　恭介、胡桃坂　仁志、西村　善文 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12339

Pages: 264-274 不適切な時間帯の運動は肺と骨格筋における時計遺伝子Period1リズムの再同調を阻害する Mistimed wheel running interferes with re-entrainment of circadian Per1 rhythms in the mouse skeletal muscle and lung 山仲　勇二郎、本間　さと、本間　研一 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12336

Pages: 275-286 Ouroタンパク質はネッタイツメガエルの変態における尾の退縮に必要では無い Ouro proteins are not essential to tail regression during Xenopus tropicalis metamorphosis 中井　裕也、中島　圭介、Jacques Robert、矢尾板　芳郎 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12337

Brief Report

Pages: 287-295 IL-18によって極性化されたM1マクロファージによる肉腫血管新生の阻害 Inhibition of blood vessel formation in tumors by IL-18-polarized M1 macrophages 邢　岩江(XING Yanjiang)、田　義軍(Yijun Tian)、黒澤　崇将、松井　さやか、藤間　真紀、呉　瓊(WU Qiong)、杉本　健吉 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12329