Vol. 20, No. 10(October 2015)

Kappa, a mischievous monster found in Japanese folklore, supposedly lives in a stream or pond, and has webbed hands and feet so that it's good at swimming. Human hands also have an interdigital web in the early embryo, but it disappears by apoptotic programmed cell death like a tadpole's tail. The intracellular signaling pathway that triggers apoptosis has been studied well; the signal flows down the 'cascade' that consists of multiple caspases (Cysteine-ASPartic proteASE) such as caspase 9 or 3 encoded by CASP9 or CASP3, respectively. This poor Kappa in this drawing has been saturated with the water flowing down the caspase cascade, and its vaunted web is in danger of disappearing by apoptosis.

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Genes to Cells © 2015 by the Molecular Biology Society of Japan and Wiley Publishing Asia Pty Ltd

Volume 20, Issue 10, 2015.

Review Article

Pages: 771-788 バトンパス仮説：哺乳類の胎盤形成に関与する内在性レトロウイルス由来の遺伝子は順次置き換わる Baton pass hypothesis: successive incorporation of unconserved endogenous retroviral genes for placentation during mammalian evolution 今川　和彦、宮沢　孝幸、中川　草 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12278

Original Articles

Pages: 789-801 バクテリア死滅期における100Sリボソームの役割 Role of 100S ribosomes in bacterial decay period Ksenia Shcherbakova、中山　秀喜、嶋本　伸雄 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12273

Pages: 802-816 電位依存性アニオンチャネルVDAC-1は線虫C. elegansの嗅覚受容に必要である Voltage-dependent anion channel (VDAC-1) is required for olfactory sensing in Caenorhabditis elegans 魚住　隆行、濱川　昌之、出野　結己、中條　信成、広津　崇亮 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12269

Pages: 817-833 ハンチンチン遺伝子に含まれる短いCCG繰り返し配列は複製型DNAポリメラーゼの障害であり複製フォークの進行を阻害する性質を持つ Short CCG repeat in huntingtin gene is an obstacle for replicative DNA polymerases, potentially hampering progression of replication fork レ　フォン　ハン、増田　雄司、釣本　敏樹、真木　智子、片山　勉、古郡　麻子、真木　寿治 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12275

Pages: 834-846 セロトニン2C型受容体pre-mRNAのA-to-I RNA編集に関わるRNA因子の同定 Identification of an RNA element for specific coordination of A-to-I RNA editing on HTR2C pre-mRNA 福田　将虎、小山　唯、西垂水　梓、尾村　美樹、野瀬　可那子、弟子丸　正伸 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12272

Pages: 847-859 ERMタンパク質によるMT1-MMPの認識とCD44分解における意義 MT1-MMP recognition by ERM proteins and its implication in CD44 shedding 寺脇　慎一、北野　健、青山　美樹、森　智行、箱嶋　敏雄 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12276

Pages: 860-870 FGFR1の自己リン酸化に関わるキナーゼドメイン間相互作用の構造基盤 Structural analysis of the mechanism of phosphorylation of a critical autoregulatory tyrosine residue in FGFR1 kinase domain 小橋川　敬博、天野　伸治郎、横川　真梨子、久米田　博之、森岡　弘志、井上　正順、Joseph Schlessinger、稲垣　冬彦 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12277