Vol. 20, No. 3(March 2015)

The fragrance of Japanese plum blossoms is the essence of early spring in Japan. This well-kept plum garden has a unique feature that it is a copy of a landscape of the outer side of animal plasma membrane. The ground represents hydrophilic head domains of the lipid molecules, while the trimmed trunks and branches in the front and the garden stones in the back look like glycosylated membrane proteins. There are a lot of plum trees that look like glycans far off in the distance. A mound on the ground under a basket and a pond in the back express lipid raft (a microdomain that has a different lipid composition) and endocytosis in process, respectively.

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Genes to Cells © 2015 by the Molecular Biology Society of Japan and Wiley Publishing Asia Pty Ltd

Volume 20, Issue 3, 2015.

Original Articles

Pages: 153-159 小胞体ストレス応答におけるIRE-1/XBP-1経路はUNC-6/Netrinの神経細胞内局在を制御し、C. elegansの軸索誘導に関与する IRE-1/XBP-1 pathway of the unfolded protein response is required for properly localizing neuronal UNC-6/Netrin for axon guidance in C. elegans 朝倉　太郎、小倉　顕一、五嶋　良郎 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12206

Pages: 160-172 分裂酵母減数分裂前期の核運動はDNA複製チェックポイントの下流で転写因子Mei4により制御される Meiotic nuclear movements in fission yeast are regulated by the transcription factor Mei4 downstream of a Cds1-dependent replication checkpoint pathway ルアン　クン、山本　孝治、淺川　東彦、近重　裕次、升方　久夫、原口　徳子、平岡　泰 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12207

Pages: 173-190 藍色細菌の概日リズム発振における時計タンパク質KaiBの単量体-二量体-四量体間のオリゴマー構造変化の重要性 Importance of the monomer-dimer-tetramer interconversion of the clock protein KaiB in the generation of circadian oscillations in cyanobacteria 飯田　高広、武藤　梨沙、小内　清、森下　めぐみ、古川　進朗、難波　啓一、石浦　正寛 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12211

Pages: 191-202 ヒトメディエーターMED17サブユニットは転写とDNA修復装置と結合することで遺伝子発現において重要な役割を果たす Human mediator MED17 subunit plays essential roles in gene regulation by associating with the transcription and DNA repair machineries 菊地　祐子、梅村　啓靖、西谷　紗織、飯田　智、深澤　力也、林　裕人、廣瀬　豊、田中　亜紀、菅澤　薫、大熊　芳明 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12210

Pages: 203-216 TFIIEのTFIIEαサブユニットのウイングド・ヘリックスモチーフのTFIIEβサブユニットあるいはTFIIBとの結合が転写における機能を区別する Association of the winged helix motif of the TFIIEα subunit of TFIIE with either the TFIIEβ subunit or TFIIB distinguishes its functions in transcription 田中　亜紀、秋元　勇亮、小林　聡子、久武　幸司、花岡　文雄、大熊　芳明 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12212

Pages: 217-223 女性ホルモンは♂マウスの肝臓におけるERαの発現・肝細胞増殖を促す Estrogen induces estrogen receptor alpha expression and hepatocyte proliferation in the livers of male mice 上尾　達也、梅田　真、今井　剛 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12214

Pages: 224-241 低酸素応答転写因子HIF-3aは接着因子VE-cadherinの発現を抑制し、肺由来血管内皮細胞の血管新生能を促進する Hypoxia-inducible factor-3α promotes angiogenic activity of pulmonary endothelial cells by repressing the expression of the VE-cadherin gene 小林　里美、山下　年晴、大根田　絹子、長野　真澄、木村　健一、中井　秀人、Lorenz Poellinger、大根田　修 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12215

Pages: 242-254 転写因子TdIF1の，ChIP-seq解析による結合配列の決定 Definition of the transcription factor TdIF1 consensus-binding sequence through genomewide mapping of its binding sites 小祝　孝太郎、久保田　隆史、渡邉　信久、堀　克敏、小祝　修、正井　久雄 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12216