Vol. 18, No. 3(March 2013)

A piece inspired by a fusion of traditional Japanese beauty and life sciences. There are a Japanese cosmetic brush and a hand mirror on a black board. An embryo fantastically reflected in the mirror suddenly reminds you of something: the brush is a very micropipette, and the embryo must be a subject of an experiment with it. How cleavage of a fertilized egg occurs is drawn like a family crest on a vanity bag, as if it indicates whom these cosmetic tools belong to. In the embryo, a lacZ marker transgene was driven by a connexin43 (Cx43) promoter in neural crest cells. Courtesy of Osamu Chisaka.

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Genes to Cells © 2013 by the Molecular Biology Society of Japan and Wiley Publishing Asia Pty Ltd

Volume 18, Issue 3, 2013.

Review Article 第9回（2011年） 日本分子生物学会三菱化学奨励賞　受賞記念

Pages: 161-175 動物細胞におけるナンセンス変異依存性mRNA分解の分子機構 Role of SMG-1-mediated Upf1 phosphorylation in mammalian nonsense-mediated mRNA decay 山下　暁朗 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12033

Review Article

Pages: 176-194 CDKおよびCDK阻害タンパク質の細胞周期調節を超えた新たな機能による脳の形成と疾患の制御機構 Extra-cell cycle regulatory functions of cyclin-dependent kinases (CDK) and CDK inhibitor proteins contribute to brain development and neurological disorders 川内　健史、鹿内　弥磨、小曽戸　陽一 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12029

Original Articles

Pages: 195-202 マイクロRNA-214と低酸素はNecl-2/CADM1の発現を抑制してErbB2/ErbB3シグナルを増強する miR-214 and hypoxia down-regulate Necl-2/CADM1 and enhance ErbB2/ErbB3 signaling 百瀬　健次、南　晶洋、下野　洋平、水谷　清人、信谷　健太郎、東　健、高井　義美 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12027

Pages: 203-210 C. elegansのRassf相同体rasf-1は酸化ストレス応答においてrab-39 Rab GTPaseと機能的に会合する C. elegans Rassf homolog, rasf-1, is functionally associated with rab-39 Rab GTPase in oxidative stress response 竹中　元彦、井上　英樹、竹島　淳史、香座　知典、堀　利行 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12028

Pages: 211-224 生体内でのグリシン受容体の凝集にはグリシン作動性伝達とポストシナプスでのCaMKII活性化が必要である Glycinergic transmission and postsynaptic activation of CaMKII are required for glycine receptor clustering in vivo 山中　衣織、三木　麻莉子、浅川　和秀、川上　浩一、小田　洋一、平田　普三 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12032

Pages: 225-237 TAF4b and TAF4 differentially regulate mouse embryonic stem cells maintenance and proliferation Anat Bahat, Ranit Kedmi, Kfir Gazit, Inna Richardo-Lax, Elena Ainbinder and Rivka Dikstein https://onlinelibrary.wiley.com/doi/10.1111/gtc.12030

Pages: 238-246 NBS1は、MRE11やTOPBP1に非依存的に、ダイレクトにATRを活性化できる NBS1 directly activates ATR independently of MRE11 and TOPBP1 小林　昌彦、林　直之、高田　穣、山本　健一 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12031