Vol. 17, No. 6(June 2012)

The Epigenetic landscape, which was firstly depicted by C. H. Waddington in 1950's, has often been used to illustrate cellular differentiation in the process of biological development. Presented on our cover is a timeless representation of the landscape where we see worshippers of Mt. Fuji are being reprogrammed on the slope. Some are climbing high to acquire pluripotency, while others are traversing the foot, and being directly reprogrammed.

---

Journal compilation © 2012 by the Molecular Biology Society of Japan/Blackwell Publishing Ltd

Volume 17, Issue 6, 2012.

Review Article

Pages: 431-438 多能性幹細胞でのゲノムDNA修正 Genome editing in induced pluripotent stem cells Li-Tao Cheng、Liang-Tso Sun、多田　高 https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2443.2012.01599.x

Original Articles

Pages: 439-454 HORMAD1に依存するチェックポイント機構が対合不全を生じた卵母細胞を除去する HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes 向後　寛、堤　真紀子、大江　瑞恵、稲垣　秀人、阿部　高也、倉橋　浩樹 https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2443.2012.01600.x

Pages: 455-472 口蓋形成過程で口蓋棚を覆うペリダーム細胞は密着結合を有しており、その剥離は口蓋棚の上皮細胞の細胞極性を低下させる Periderm cells covering palatal shelves have tight junctions and their desquamation reduces the polarity of palatal shelf epithelial cells in palatogenesis 吉田　美登里、下野　洋平、富樫　英、松崎　聖美、三好　淳、溝口　明、古森　孝英、高井　義美 https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2443.2012.01601.x

Pages: 473-493 サイクリン依存性キナーゼによるLif1とSae2のリン酸化は、DNA二重鎖切断末端の削り込みを伴った不正確な非相同末端結合を制御する Cyclin-dependent kinase-dependent phosphorylation of Lif1 and Sae2 controls imprecise nonhomologous end joining accompanied by double-strand break resection 松嵜　健一郎、寺澤　匡博、岩﨑　大地、東出　望花、篠原　美紀 https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2443.2012.01602.x

Pages: 494-508 聴覚・色素異常症のモデルであるMitf ^mi-bwマウスでは、メラノブラストの分化が障害されている Impaired development of melanoblasts in the black-eyed white Mitf ^mi-bw mouse, a model for auditory-pigmentary disorders 穂積　大貴、武田　和久、天野　恭子、竹本　祐史、楠見　僚太、福崎－土肥　麗、東谷　篤志、山本　博章、柴原　茂樹 https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2443.2012.01603.x

Pages: 509-524 コヒーシンは７回膜貫通型カドヘリンFlamingoの量を介して平面内細胞極性を制御する Cohesin controls planar cell polarity by regulating the level of the seven-pass transmembrane cadherin Flamingo 毛利　亘輔、堀内　伸也、上村　匡 https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2443.2012.01604.x