Vol. 18, No. 6(June 2013)

kaiA, kaiB and kaiC genes and their products constitute a core circadian oscillator in the cyanobacterium S. elongates (derived from a Japanese term “kai”, which means rotation or cycle number). KaiA stimulates autophosphorylation of KaiC, whereas KaiB promotes autodephosphorylation of KaiC. It is the particular characteristics of system of cyanobacteria that the three purified Kai proteins and ATP can reconstitute a circadian oscillation in a test tube. We overlay a diagram of this feedback loop on an armillary sphere in an Ukiyoe, which was installed at an astronomical observatory in Edo era. The pattern of roof tiles in the foreground depicts a circadian oscillation.

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Genes to Cells © 2013 by the Molecular Biology Society of Japan and Wiley Publishing Asia Pty Ltd

Volume 18, Issue 6, 2013.

Original Articles

Pages: 425-441 出芽酵母Mih1/Cdc25はPkc1により負に制御される Mih1/Cdc25 is negatively regulated by Pkc1 in Saccharomyces cerevisiae 矢野　興一朗、上園　幸史、吉田　知史、菊池　韶彦、柏崎　隼、馬渕　一誠、菊池　淑子 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12047

Pages: 442-449 WNK4はFGFシグナルによる頭部形成制御に関与する WNK4 is an essential effector of anterior formation in FGF signaling 清水　幹容、後藤　利保、佐藤　淳、澁谷　浩司 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12048

Pages: 450-458 ヘテロ二重鎖検出法を用いたTALENによるゲノム改変の効率的な検出 Efficient identification of TALEN-mediated genome modifications using heteroduplex mobility assays 太田　聡、久野　悠、村木　倫子、星島　一幸、Timothy J. Dahlem、David J. Grunwald、岡田　康志、川原　敦雄 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12050

Pages: 459-475 酵母Nedd4様ユビキチンリガーゼRsp5はThr357のリン酸化によってアミノ酸パーミアーゼGap1の活性を制御している Phosphorylation of a conserved Thr357 in yeast Nedd4-like ubiquitin ligase Rsp5 is involved in down-regulation of the general amino acid permease Gap1 佐々木　俊弥、高木　博史 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12049

Pages: 476-492 蛍光強度測定によるペルオキシソームマトリクスタンパク質輸送効率測定法の確立 System to quantify the import of peroxisomal matrix proteins by fluorescence intensity 野口　雅史、奥本　寛治、藤木　幸夫 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12051

Pages: 493-501 抗ウイルス応答分子IPS-1のミトコンドリアへの局在は、caspaseの活性化能に重要である Mitochondrial localization of the antiviral signaling adaptor IPS-1 is important for its induction of caspase activation 岡崎　朋彦、樋口　麻衣子、後藤　由季子 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12052

Pages: 502-518 FASTER法: マウスにおける睡眠覚醒状態の教師なし自動判定 FASTER: an unsupervised fully-automated sleep staging method for mice 砂川　玄志郎、勢井　宏義、榛葉　繁紀、裏出　良博、上田　泰己 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12053

Pages: 519-528 Necl-4/CADM4とErbB3およびインテグリンα₆β₄の相互作用とErbB2/ErbB3シグナル伝達とヘミデスモソーム崩壊の阻害 Interaction of Necl-4/CADM4 with ErbB3 and integrin α₆β₄ and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly 杉山　宏和、水谷　清人、栗田　宗一、沖元　斉正、下野　洋平、高井　義美 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12056