Vol. 19, No. 12(December 2014)

Genpaku Sugita (1733-1817) is well-known for his translation of 'Kaitai Shinsho' (New Text on Anatomy, in 1774) compiled based on a book of anatomy written in Dutch. This Japanese first full-blown translation from a Western language contributed to the development of medical science in Japan. The masterpiece has been accomplished while many translated terms such as "shinkei" (= nerve) were coined. Over the past 240 years since then, anatomical methods have dramatically improved. Various optical clearing agents have been invented to clear organs including the brain without difficulty. Now, those agents can make brains transparent without damaging any of the fine structures, and enable researchers to observe neurons deep inside the brain. With our great respect to Genpaku Sugita, let us give him components of the optical clearing agents: urea, detergents and aminoalcohol. Behind him stands a vase of a soapberry tree bearing fruit that used to be raw material for detergents in Edo era.

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Genes to Cells © 2014 by the Molecular Biology Society of Japan and Wiley Publishing Asia Pty Ltd

Volume 19, Issue 12, 2014.

Original Articles

Pages: 853-863 s-アファディンはl-アファディンよりも細胞接着分子ネクチンにより強く結合する s-Afadin binds more preferentially to the cell adhesion molecules nectins than l-afadin 小林　礼子、栗田　宗一、宮田　宗明、丸尾　知彦、萬代　研二、力武　良行、高井　義美 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12185

Pages: 864-878 Nrf2は糖尿病マウスにおけるFGF21の発現を誘導する Nrf2 induces fibroblast growth factor 21 in diabetic mice 古澤　祐樹、宇留野　晃、柳下　陽子、東　知佳、山本　雅之 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12186

Pages: 879-890 転写コファクターPC4は基本転写因子TFIIEの小サブユニットと共同して重要な役割を果している Transcription cofactor PC4 plays essential roles in collaboration with the small subunit of general transcription factor TFIIE 秋元　勇亮、山本　誠司、飯田　智、廣瀬　豊、田中　亜紀、花岡　文雄、大熊　芳明 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12187

Pages: 891-900 ClpBシャペロンは可溶性変性タンパク質を受動的に糸通しする ClpB chaperone passively threads soluble denatured proteins through its central pore 中﨑　洋介、渡辺　洋平 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12188

Pages: 901-918 拡張型心筋症に関連するラミンＡ変異体の長期間発現は老化を誘導する Long-term expression of the lamin A mutant associated with dilated cardiomyopathy induces senescence 森内　昂文、村岡　拓也、三尾　和弘、大隅　隆、廣瀬　富美子 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12189

Pages: 919-926 SraTailor：誰でも簡単に使える、ChIP-seq データの可視化ツール SraTailor: Graphical user interface software for processing and visualizing ChIP-seq data 沖　真弥、前原　一満、大川　恭行、目野　主税 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12190

Pages: 927-940 TTBK2の中心小体への局在と一次繊毛形成機能には、EB1との結合は必須でなく、Cep164との結合が必須である Binding to Cep164, but not EB1, is essential for centriolar localization of TTBK2 and its function in ciliogenesis 小田　聡明、千葉　秀平、永井　友朗、水野　健作 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12191