Vol. 20, No. 9(September 2015)

Shoki (Zhong Kui in Chinese), derived from Chinese Taoism, is a god for warding off diseases. According to a legend, one night when Emperor Genso (Xuanzong) of the Tang Dynasty had a high fever, Shoki appeared to him in a dream, killed a monster, and saved the Emperor at last. In tribute to the legend, Shoki has been worshipped as a god who protects people from illness for hundreds of years in China and Japan. The role of Shoki in the legend is that of the immune system itself. In this drawing, Shoki holds a sasumata (spear fork) with an IgG-like spearhead in the right hand and wears a cloth with a crest of IgM and a pattern of a dendritic cell; they are weapons of mammalian adaptive immunity. In contrast, his left hand contains a monster (pathogen) by melanization, which is one of the weapons of the innate immunity of insects. We thank Prof. Hirotaka Kanuka's lab (The Jikei University School of Medicine) for their valuable suggestions for our drawing.

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Genes to Cells © 2015 by the Molecular Biology Society of Japan and Wiley Publishing Asia Pty Ltd

Volume 20, Issue 9, 2015.

Original Articles

Pages: 681-694 hCAS/CSE1Lは相同組換え修復のためにRAD51の細胞内分布と核内フォーカス形成を制御する hCAS/CSE1L regulates RAD51 distribution and focus formation for homologous recombinational repair 沖本　聡志、孫　継英、福戸　敦彦、堀越　保則、松田　俊、松田　知成、井倉　正枝、井倉　毅、町田　晋一、胡桃坂　仁志、宮本　洋一、岡　正啓、米田　悦啓、木内　良明、田代　聡 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12262

Pages: 695-705 分裂酵母ではアゾール系化合物がMAPキナーゼ経路を介してAtf1による転写を活性化し抗真菌作用を発揮する Azoles activate Atf1-mediated transcription through MAP kinase pathway for antifungal effects in fission yeast 胡　玲玲、房　月、早藤　励、馬　艶、古屋敷　智之 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12263

Pages: 706-719 NF-κBシグナルは発生期大脳皮質における中間型幹細胞の発生を調節する NF-κB signaling regulates the generation of intermediate progenitors in the developing neocortex 山西　恵美子、Keejung Yoon、Lavinia Alberi、Nicholas Gaiano、水谷　健一 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12267

Pages: 720-738 転写因子Lhx2によるマウス多能性幹細胞からの効率的なT細胞の産生 Efficient production of T cells from mouse pluripotent stem cells by controlled expression of Lhx2 北島　健二、川口　真実、宮下　和也、中島　鞠乃、鹿子田　真衣、原　孝彦 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12266

Pages: 739-757 ヒト正常線維芽細胞における制御を外れたE2Fの新規標的遺伝子の同定 Identification of novel target genes specifically activated by deregulated E2F in human normal fibroblasts 北村　穂高、大園　瑛子、岩永　律子、Andrew P. Bradford、奥野　潤子、清水　恵美、倉吉　健太、久川　和之、藤　博幸、大谷　清 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12268

Pages: 758-770 Prdm8の欠損は、大脳皮質上層ニューロンの発生に異常を示す Deletion of Prdm8 impairs the development of the upper-layer neocortical neurons 井上　真悠子、岩井　亮太、山西　恵美子、山形　一行、鈴木　真理子、本田　文、駒井　妙、宮地　均、北野　さつき、渡部　千里、手島　羽香、水谷　健一 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12274