Vol. 22, No. 8(August 2017)

Mutations in PARKIN or PINK1 genes can cause autosomal recessive juvenile Parkinson's disease. In recent years, it has been revealed that they participate in mitochondrial quality control. Their products, Parkin and PINK1, modify dysfunctional mitochondria with polyubiquitin chains to promote selective autophagy (mitophagy) that eliminates dysfunctional mitochondria from cells. The woman in this drawing is removing unwanted seeds from the watermelon just as mitophagy eliminates dysfunctional mitochondria.

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Genes to Cells © 2017 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 22, Issue 8, 2017.

Original Articles

Pages: 684-698 小胞体タンパク質SDF2とSDF2L1はBiPシャペロンサイクルの一員として機能し、タンパク質の凝集を抑制する Endoplasmic reticulum proteins SDF2 and SDF2L1 act as components of the BiP chaperone cycle to prevent protein aggregation 藤森　力、寿野　良二、家村　俊一郎、夏目　徹、和田　郁夫、細川　暢子 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12506

Pages: 699-714 Two zinc finger proteins from Mycobacterium smegmatis: DNA binding and activation of transcription Subho Ghosh and Dipankar Chatterji https://onlinelibrary.wiley.com/doi/10.1111/gtc.12507

Pages: 715-722 苔状線維シナプスの機能分化におけるアファディンの役割 Roles of afadin in functional differentiations of hippocampal mossy fiber synapse 耿　瀟奇、丸尾　知彦、萬代　研二、Irwan Supriyanto、宮田　宗明、榊原　正太郎、溝口　明、高井　義美、森　正弘 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12508

Pages: 723-741 メダカとゼブラフィッシュcontactin1b変異体は運動協調性を制御する神経回路の理解のための良いモデルを提供する Medaka and zebrafish contactin1 mutants as a model for understanding neural circuits for motor coordination 竹内　未紀、井上　慎子、五島　明子、長尾　勇佑、清水　宏一、宮本　大輝、清水　貴史、橋本　寿史、米村　重信、川原　敦雄、平田　豊、吉田　将之、日比　正彦 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12509

Pages: 742-755 NGL-3に誘導される海馬神経細胞シナプス前部の分化はアファディンに依存しているがネクチンには依存していない NGL-3-induced presynaptic differentiation of hippocampal neurons in an afadin-dependent, nectin-1-independent manner 丸尾　知彦、萬代　研二、宮田　宗明、榊原　正太郎、王　淑杰、崔　煌植、伊藤　優、垣内　愛加、藤原　武志、溝口　明、高井　義美 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12510

Brief Report

Pages: 756-763 CRISPR/Cas9システムを用いたF0ノックアウトメダカの作製 Generation of biallelic F0 mutants in medaka using the CRISPR/Cas9 system 澤村　理英、長船　奈津美、村上　貴浩、古川　史弥、北野　健 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12511