Vol. 26, No. 9(September 2021)

Advances in optogenetic techniques, in which light-activated proteins that respond to specific wavelengths are expressed in specific cells, have made it possible to manipulate the activity of specific nerves in many animal species including mammals with high temporal and spatial precision. The method of using optical fiber for light irradiation (right) is highly invasive and restricts behavior of animal. However, new methods to overcome this problem have emerged. Some examples are a method of using implantable wireless light-emitting devices (top left), and a method of injecting upconversion nanoparticles that emit visible light in response to near-infrared (NIR) lights that reach deep into the body (center; the light emitted from Uchide-no-kozuchi (magic mallet) of Daikokuten is NIR).

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Genes to Cells © 2021 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 26, Issue 9, 2021.

Review Article

Pages: 641-683 Necdin (ネクディン) による哺乳類のニューロンを永続させる分子間相互作用ネットワーク統御 Necdin: A purposive integrator of molecular interaction networks for mammalian neuron vitality 吉川　和明 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12884

Original Articles

Pages: 684-697 miR-29c-3p regulates TET2 expression and inhibits autophagy process in Parkinson's disease models Ruili Wang, Jie Yao, Fuhua Gong, Songsheng Chen, Ya He, Chunting Hu and Chen Li https://onlinelibrary.wiley.com/doi/10.1111/gtc.12877

Pages: 698-713 ヒメツリガネゴケにおいて赤色光に制御されたPer-Arnt-SimヒスチジンキナーゼのパートナーHPtタンパク質との相互作用 Red light-regulated interaction of Per-Arnt-Sim histidine kinases with partner histidine-containing phosphotransfer proteins in Physcomitrium patens 阿南　秀、山篠　貴史、鈴木　遼、中井　皐太、佐藤　健介、呉　博文、龍　昌志、杉田　護、青木　摂之 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12878

Pages: 714-726 成体マウスの唾液腺においてTAZは、腺房細胞への分化を抑制し、未分化な腺管細胞を増加させる TAZ inhibits acinar cell differentiation but promotes immature ductal cell proliferation in adult mouse salivary glands 宮地　洋佑、西尾　美希、大谷　淳二、松本　真司、菊池　章、Tak Wah Mak、前濱　朝彦、鈴木　聡 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12879

Pages: 727-738 シロイヌナズナ葉緑体のCds4/5の大腸菌における発現によるCDPジアシルグリセロール生合成酵素のC末端領域の膜配向性の決定 Expression of Cds4/5 of Arabidopsis chloroplasts in E. coli reveals the membrane topology of the C-terminal region of CDP-diacylglycerol synthases 関谷　優晟、沢里　克宏、西山　賢一 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12880

Pages: 739-751 ハイスループットスクリーニングによって同定された微小管阻害剤は遺伝子導入効率をp62依存的に促進する Microtubule inhibitors identified through non-biased screening enhance DNA transfection efficiency by delaying p62-dependent ubiquitin recruitment 土屋　惠、小川　英知、渡邊　賢人、荒神　尚子、森　知栄、布村　一人、林　邦忠、谷　昭義、平岡　泰、原口　徳子 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12881