Vol. 26, No. 10(October 2021)

A competition of protein 3D structure prediction. It is about how similar the predictions are to the correct answer (the actual experimental result), which is slightly to the right of the center. The prediction placed on the left of the correct answer was done by an AI, and won the first prize. AI has made remarkable progress in recent years, and in a contest held in 2020 (CASP14), the predictions made by AlphaFold 2, an AI developed by DeepMind, finally reached a level comparable to actual experimental results. The 3D structures shown here were drawn with PyMOL based on the PDB files of target ID T1053 and its prediction models downloaded from CASP14 website (https://www.predictioncenter.org/casp14/index.cgi).

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Genes to Cells © 2021 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 26, Issue 10, 2021.

Original Articles

Pages: 757-771 マイクロRNAを含む両生類の栓球細胞由来の細胞外小胞は、内皮細胞に血管新生関連遺伝子の発現を誘導する Amphibian thrombocyte-derived extracellular vesicles, including microRNAs, induce angiogenesis-related genes in endothelial cells 杉本　健吉、當銘　香也乃 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12882

Pages: 772-781 MiR-382-5p suppresses M1 macrophage polarization and inflammatory response in response to bronchopulmonary dysplasia through targeting CDK8: Involving inhibition of STAT1 pathway Yuanyuan Lv, Yang Li, Jiangya Wang, Mei Li, Wenhao Zhang, Huifen Zhang, Ying Shen, Chao Li, Yuan Du and Lian Jiang https://onlinelibrary.wiley.com/doi/10.1111/gtc.12883

Pages: 782-797 赤血球前駆細胞上のエンドグリンに対するBMP9結合阻害により、マウスにおいて赤血球造血が亢進される Blockade of the interaction between BMP9 and endoglin on erythroid progenitors promotes erythropoiesis in mice 山口　理美、平野　育生、成澤　志保、清水　清、有山　博之、山脇　健吾、長尾　研二、山本　雅之、清水　律子 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12887

Pages: 798-806 線虫において、ヒトMOB4のホモログが欠損すると、生命寿命、健康寿命、熱耐性が障害される Loss of Caenorhabditis elegans homologue of human MOB4 compromises life span, health life span and thermotolerance Momotaj Jahan、岩佐　宏晃、黒柳　秀人、畑　裕 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12891

Pages: 807-822 分泌型好中球プロテアーゼ阻害因子（SLPI）のプロテアーゼ阻害活性は腸管上皮バリアを保護することでマウス実験腸炎を軽減する Protease inhibitory activity of secretory leukocyte protease inhibitor ameliorates murine experimental colitis by protecting the intestinal epithelial barrier 小坂　聡太郎、園田　光、有木　晋平、神山　長慶、飛彈野　真也、佐知　望美、伊藤　加奈子、工藤　洋子、皆田　美月、Benjawan Saechue、Astri Dewayani、Thanyakorn Chalalai、曽我　泰裕、高橋　優也、福田　千瑛、水上　一弘、奥村　龍、香山　尚子、村上　和成、竹田　潔、小林　隆志 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12888

Brief Reports

Pages: 823-829 酵母Saccharomyces cerevisiaeにおける一酸化窒素誘導性転写因子Fzf1の活性化には4番目の亜鉛フィンガー内のシステイン残基が重要である Cysteine residues in the fourth zinc finger are important for activation of the nitric oxide-inducible transcription factor Fzf1 in the yeast Saccharomyces cerevisiae 那須野　亮、吉岡　奈津子、吉川　雄樹、高木　博史 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12885

Pages: 830-837 SET-NUP214とMLLは協調的にHoxA10遺伝子のプロモーター活性を制御する SET-NUP214 and MLL cooperatively regulate the promoter activity of the HoxA10 gene Sadik Cigdem、齋藤　祥子、西方　大貴、永田　恭介、奥脇　暢 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12886