Vol. 26, No. 11(November 2021)

A woman enduring the heat of moxibustion, using a box with chili peppers on top as a pillow. The nonselective cation channel TRPV1 (schematically depicted on her kimono and the side of the box below her) is a receptor that responds to capsaicin, the pungent component of chili pepper, and heat above 43°C, making us feel heat and pain. Prof. David Julius, who discovered TRPV1, will be awarded the Nobel Prize in Physiology or Medicine in 2021 (jointly with Prof. Ardem Patapoutian for the discovery of receptors for mechanical stimuli).

---

Genes to Cells © 2021 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 26, Issue 11, 2021.

Review Article

Pages: 843-860 Post-translational modifications of proteins associated with yeast peroxisome membrane: An essential mode of regulatory mechanism Terence Infant, Rachayeeta Deb, Suchetana Ghose and Shirisha Nagotu https://onlinelibrary.wiley.com/doi/10.1111/gtc.12892

Original Articles

Pages: 861-873 桑の実の抽出物は神経細胞内にアミロイドβオリゴマーを発現するアルツハイマー病モデルマウスの認知機能障害と酸化ストレスを緩和する Mulberry fruit extract alleviates the intracellular amyloid-β oligomer-induced cognitive disturbance and oxidative stress in Alzheimer's disease model mice 落石　知世、角　正美、Tanwarat Kajsongkram、Krittiya Thisayakorn https://onlinelibrary.wiley.com/doi/10.1111/gtc.12889

Pages: 874-890 転写活性を持つ新たなゲノム要素CSCT：染色体特異的にクラスターを形成しているトラップ領域 Gene trapping reveals a new transcriptionally active genome element: The chromosome-specific clustered trap region 武田　伊世、荒木　正健、石黒　啓一郎、大賀　俊範、高田　幸基、山口　友輔、橋本　紘一、甲斐　拓篤、中潟　直己、今坂　舞、吉信　公美子、荒木　喜美 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12890

Pages: 891-904 新規一本鎖RNAベクターを利用した治療用イズロン酸-2-スルファターゼの発現 Production of therapeutic iduronate-2-sulfatase enzyme with a novel single-stranded RNA virus vector 大平　麻里、菊池　亜美花、水田　志織、吉田　尚美、小野寺　雅史、中西　真人、奥山　虎之、真嶋　隆一 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12894

Pages: 905-926 Znフィンガータンパク質と抗FLAG、抗HA細胞内キメラ抗体「フランケンボディ」 を用いた内在性ゲノム領域ループの生細胞可視化 Visualizing looping of two endogenous genomic loci using synthetic zinc-finger proteins with anti-FLAG and anti-HA frankenbodies in living cells Yang Liu、Ning Zhao、鐘巻　将人、山本　陽太郎、定村　佳房、伊藤　由馬、徳永　万喜洋、Timothy J. Stasevich、木村　宏 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12893

Pages: 927-937 海洋性ビブリオ菌の走化性に必須な極べん毛モーター回転方向制御を担うZomB ZomB is essential for chemotaxis of Vibrio alginolyticus by the rotational direction control of the polar flagellar motor 竹川　宜宏、錦野　達郎、堀　清志郎、小嶋　誠司、今田　勝巳、本間　道夫 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12895