Vol. 27, No. 1(January 2022)

At a New Year’s banquet, an entertainer is performing a juggling trick in which a DNA-like string is temporarily cleaved and another string passes through it using a eukaryotic topoisomerase II-mimicking ‘top.’ This trick requires ATP. In humans, topoisomerase IIα is highly expressed in proliferating cells and is essential for DNA replication, transcription, and structural maintenance and proper segregation of mitotic chromosomes, resulting in an important target for anticancer drugs.

---

Genes to Cells © 2022 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 27, Issue 1, 2022.

Original Articles

Pages: 5-13 ウシ脱分化脂肪細胞 (DFAT) の脂肪細胞分化に及ぼす種々の揮発性脂肪酸の影響 Effect of volatile fatty acids on adipocyte differentiation in bovine dedifferentiated fat (DFAT) cells in vitro 沖　嘉尚、萩原　玲子、松丸　卓史、加野　浩一郎 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12903

Pages: 14-24 LincRNA-p21のエキソン1の発現量は生体内においてCdkn1aの発現量と相関する LincRNA-p21 exon1 expression correlates with Cdkn1a expression in vivo 古畑　理樹、今坂　舞、杉本　道彦、吉信　公美子、荒木　正健、荒木　喜美 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12906

Pages: 25-42 グリオーマ細胞は癌幹細胞の自己増殖戦略として赤血球産生を遠隔的に促進する Glioma cells remotely promote erythropoiesis as a self-expanding strategy of cancer stem cells Alapati Aimaitijiang、椨　康一、Wenqian Wang、信久　幾夫、田賀　哲也 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12908

Pages: 43-60 細胞タイプ特異的なER膜タンパク質UGS148はマウスにおいて必須ではない The cell type-specific ER membrane protein UGS148 is not essential in mice 高橋　理、棚橋　まゆ子、横井　佐織、金子　麻里、屋中　香織、中川　真一、米田　宏 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12910

Pages: 61-71 CHD4に結合する新規タンパク質の同定と機能解析 Identification and characterization of novel proteins associated with CHD4 坂口　千尋、市原　知哉、仁田　暁大、片山　雄太、中山　敬一 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12909