Vol. 27, No. 3(March 2022)

The Hi-C method (a method to examine genomic regions that are close to each other in the nucleus by fragmenting and ligating cross-linked nuclear chromatin and then reading the paired-end sequences by NGS) has revealed the existence of structural units called topologically associating domains (TADs) that are separated by insulators in the genome. When the results of the Hi-C method are drawn as a heatmap, TADs appear as characteristic diamond-shaped signals, with deeper colors indicating the higher probability that regions of the genome are closer to each other. We drew them on Hishimochi rice cakes (diamond-shaped rice cakes), an essential decoration for the Japanese Doll's Festival on March 3. We thank Drs. Ichiro Hiratani and Hisashi Miura (RIKEN BDR) for providing the data.

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Genes to Cells © 2022 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 27, Issue 3, 2022.

Review Article

Pages: 157-172 細菌セカンドメッセンジャーであるc-di-GMPの役割：ビブリオ菌のべん毛制御に関することに焦点にして Roles of the second messenger c-di-GMP in bacteria: Focusing on the topics of flagellar regulation and Vibrio spp. 本間　道夫、小嶋　誠司 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12921

Original Articles

Pages: 173-191 Importin α IBB domainの生化学的性質マッピングによる構造及び機能分析 Biochemical propensity mapping for structural and functional anatomy of importin α IBB domain 地引　和也、劉　墨言、雷　钞森、児玉　高志、児嶋　長次郎、藤原　敏道、安原　徳子 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12917

Pages: 192-201 妊娠期母体肝臓における胆管上皮細胞のダイナミクス Delineation of biliary epithelial cell dynamics in maternal liver during pregnancy 上月　智司、櫻井　智子、鈴木　淳史、山本　拓也、豊島　文子 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12918

Pages: 202-213 CREG1はUCP1依存性作用により食事誘導性肥満を改善する CREG1 improves diet-induced obesity via uncoupling protein 1-dependent manner in mice 遠藤　優貴、橋本　理尋、楠堂　達也、岡田　只士、竹内　環、後藤　亜由美、山下　均 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12920

Pages: 214-228 低侵襲超解像ライブセルイメージングシステムを用いたマウス受精卵の染色体カウント Chromosome counting in the mouse zygote using low-invasive super-resolution live-cell imaging 波多野　裕、増子　大輔、野老　美紀子、八尾　竜馬、山縣　一夫 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12925

Brief Report

Pages: 229-237 培養条件とp14ARF, p53のステータスに依存したp27Kip1の差異的制御 Differential regulation of p27Kip1 depending on culture conditions and its correlation with status of p14ARF and p53 米谷　達哉、河崎　優太郎、千葉櫻　拓 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12919