Vol. 27, No. 12(December 2022)

Two pairs of “look-alikes” that match SNPs. Comparisons of multi-omics and lifestyle were made between look-alikes who were not genetically related but had similar faces (Joshi et al. (2022) Cell Reports 40: 111257, DOI: 10.1016/j.celrep.2022.111257). The results showed that among pairs of “look-alike,” the rate of matching SNPs related to facial features was high. In addition, height, weight, smoking habits, and education also had correlations. On the other hand, DNA methylome and microbiome were not similar. This study may provide clues as to how much the extent to which the genome sequence and environmental factors contribute to physical and behavioral traits.

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Genes to Cells © 2022 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 27, Issue 12, 2022.

Original Articles

Pages: 689-705 翻訳開始因子 INT6/eIF3e はヒト肺腺癌 A549 細胞において転写因子 HIF2α を介して E-cadherin 遺伝子発現を抑制する INT6/eIF3e represses E-cadherin expression through HIF2α in lung carcinoma A549 cells 齊藤　紗希、貞任　大地、芝﨑　太 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12984

Pages: 706-718 ウェブベースプラットフォームを用いたSITE-Seq解析によるゲノム編集イネのオフターゲット候補サイトの偏りのない予測 Unbiased prediction of off-target sites in genome-edited rice using SITE-Seq analysis on a web-based platform 成島　純平、木俣　真弥、志波　優、権藤　崇裕、秋本　智、曽我　慶介、吉場　聡子、中村　公亮、柴田　識人、近藤　一成 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12985

Pages: 719-730 マウス肝がん由来細胞株におけるヘムオキシゲナーゼ-1発現の熱ショック誘導性はHSF1に依存し、NRF2とBACH1によって調節される Heat shock-induced heme oxygenase-1 expression in a mouse hepatoma cell line is dependent on HSF1 and modified by NRF2 and BACH1 井上　幸江、久保　貴紀、宮本　崇史、伊豫田　拓也、沖田　直之、赤木　玲子 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12986

Pages: 731-740 BAP1はヒトBリンパ芽球細胞において自然免疫関連サイトカイン・ケモカイン発現を制御する BAP1 depletion in human B-lymphoblast cells affects the production of innate immune cytokines and chemokines 木村（高木）　美智、多田　陽郎、木島　貴志、久保　秀司、大村谷　昌樹、吉川　良恵 https://onlinelibrary.wiley.com/doi/10.1111/gtc.12988