Vol. 29, No. 4(April 2024)

TBXT遺伝子にAluYが刺さって尻尾を失う孫悟空
Son Goku (Sun Wukong), a god in monkey form, was brandishing a Nyoi-bo representing the TBXT gene. However, an AluY-marked dagger hit the Nyoi-bo and broke it off. Xia et al. showed that the loss of tails in hominoids, including humans and apes, was due in part to changes in splicing patterns caused by the insertion of an AluY element into the ancestral TBXT gene (Xia et al. (2024) Nature 626:1042-1048, DOI: 10.1038/s41586-024-07095-8). Son Goku cannot hide the look of impatience on his face as his tail begins to disappear, having impaired the function of the Nyoi-bo, which is necessary to maintain his tail, the source of Son Goku's magical power.

Genes to Cells © 2024 the Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Volume 29, Issue 4, 2024.

Special Feature

Pages: 275-281 オープンサイエンスの時代における科学出版の諸問題 Publishing in the Open Access and Open Science era 有田 正規、Bernd Pulverer、上村 匡、佐久間 知佐子、林 茂生 https://onlinelibrary.wiley.com/doi/10.1111/gtc.13100

Original Articles

Pages: 282-289 ビブリオ菌べん毛モーター固定子タンパク質PomBの膜貫通領域とペプチドグリカン結合領域を繋ぐリンカー領域の役割 Roles of linker region flanked by transmembrane and peptidoglycan binding region of PomB in energy conversion of the Vibrio flagellar motor 宮村 優輔、錦野 達郎、小岩 大晃、本間 道夫、小嶋 誠司 https://onlinelibrary.wiley.com/doi/10.1111/gtc.13102 Pages: 290-300 C9orf10/Ossaはマウスモデルにおける樹立した肺腺癌細胞サブラインH322L-BO4の骨転移を制御する C9orf10/Ossa regulates the bone metastasis of established lung adenocarcinoma cell subline H322L-BO4 in a mouse model 上北 尚正、八木 玲子、市村 徹、堺 隆一 https://onlinelibrary.wiley.com/doi/10.1111/gtc.13103 Pages: 301-315 多数の乳がん細胞株を用いた抗アンドロゲン薬感受性評価 Analysis of the responsiveness to antiandrogens in multiple breast cancer cell lines 黒岩 由佳、伊藤 景紀、中山 淳、仙波 憲太郎、山本 雄介 https://onlinelibrary.wiley.com/doi/10.1111/gtc.13105 Pages: 316-327 自然免疫受容体Dectin-1を介した自己成分の認識は肝炎を増悪させる Self-recognition through Dectin-1 exacerbates liver inflammation 鳥越 祥太、Douglas W. Lowman、杉木 俊彦、David L. Williams、山﨑 晶 https://onlinelibrary.wiley.com/doi/10.1111/gtc.13106

Brief Reports

Pages: 328-336 カテプシンLは細胞モデルにおいてαシヌクレイン凝集体の蓄積を抑制する Cathepsin L prevents the accumulation of alpha-synuclein fibrils in the cell 松木 あゆみ、渡邊 義久、橋本 翔、星野 温、的場 聖明 https://onlinelibrary.wiley.com/doi/10.1111/gtc.13099 Pages: 337-346 Microtubule-affinity regulating kinase ファミリーのメンバーは、タウオパチーモデルショウジョウバエで、タウのリン酸化と神経細胞死にそれぞれ異なる影響を与える Microtubule-affinity regulating kinase family members distinctively affect tau phosphorylation and promote its toxicity in a Drosophila model Grigorii Sultanakhmetov、加藤 伊織、淺田 明子、斎藤 太郎、安藤 香奈絵 https://onlinelibrary.wiley.com/doi/10.1111/gtc.13101 Pages: 347-355 リン脂質および糖脂質MPIase生合成に関与するCDP-ジアシルグリセロール生合成酵素:CdsAの開始コドンの決定 CdsA, a CDP-diacylglycerol synthase involved in phospholipid and glycolipid MPIase biosynthesis, possesses multiple initiation codons 日景 瑠那、関谷 優晟、沢里 克宏、西山 賢一 https://onlinelibrary.wiley.com/doi/10.1111/gtc.13104