At first glance, it might seem to be a Japanese rock garden (karesansui) with wavy lines in the sand (samon); however, it is actually an electron microscopic photograph of Drosophila midgut epithelium taken with the freeze-fracture method. The lines that look like samon are smooth septate junctions, which are a kind of occluding junction seen in invertebrates. We thank Prof. Mikio Furuse and Ms. Kyoko Furuse (National Institute for Physiological Sciences) for providing the data and sharing the idea of karesansui.
This is an acrobatic performance imitating immunoprecipitation using a phosphorylated protein-specific antibody. Two boys are acting two forms of a substrate protein. The boy on the left who wears red trousers, that represent the phosphorylation site of the substrate protein, is showing an opened fan and striking a pose that looks like the active form of the substrate protein. The other one who wears blue trousers is squatting on the ground to play the role of the dephosphorylated, inactive form of the substrate protein. The man who is suspended upside down in the midair is acting a phosphor-specific antibody, and grasping the red trousers only, i.e. the site of phosphorylation.